抗体对TRIC生物体的中和作用：抗免疫球蛋白制备的抗血清的增强作用。
Neutralization of TRIC organisms by antibody: enhancement by antisera prepared against immunoglobulins.
作者信息
Blyth W A, Taverne J
出版信息
J Hyg (Lond). 1974 Feb;72(1):129-34. doi: 10.1017/s0022172400023299.
Abstract
The neutralizing activities of fowl, rabbit and mouse antisera prepared against TRIC agents were enhanced, in some cases over a 100-fold, by the addition of antiserum against the appropriate IgG. Significant non-specific inactivation of the organisms was observed in the absence of antiserum against TRIC agents, in reaction mixtures containing normal serum and antiserum against IgG. Since the extent of this inactivation showed a prozone, control tests with dilutions of normal serum equivalent to the full range of dilutions of the antiserum tested are necessary to show that enhancement of neutralization is specific.
摘要
用抗TRIC病原体制备的鸡、兔和小鼠抗血清的中和活性，在某些情况下通过添加针对相应IgG的抗血清而增强，增强幅度超过100倍。在不含抗TRIC病原体抗血清的情况下，在含有正常血清和抗IgG抗血清的反应混合物中观察到病原体明显的非特异性失活。由于这种失活程度呈现前带现象，因此需要用与所测试抗血清的全系列稀释度相当的正常血清稀释液进行对照试验，以表明中和作用的增强是特异性的。
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