宿主免疫反应与沙眼衣原体从人宫颈定量恢复之间的相关性。
Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix.
作者信息
Brunham R C, Kuo C C, Cles L, Holmes K K
出版信息
Infect Immun. 1983 Mar;39(3):1491-4. doi: 10.1128/iai.39.3.1491-1494.1983.
Abstract
We studied 95 women with uncomplicated Chlamydia trachomatis cervical infection. Quantitative isolation of C. trachomatis was performed in HeLa 229 cells, and the results were correlated with serum immunoglobulin M and immunoglobulin G antibody to the organism. We found that quantitative cultures for C. trachomatis can provide a meaningful measurement by which to evaluate the effect of the acquired immune response. In particular, secretory immunoglobulin A antibody to C. trachomatis in cervical secretion demonstrated a striking and inverse correlation with recovery of the organism from the cervix. It is suggested that this component of the immune response may regulate shedding of the organism.
摘要
我们研究了95例患有单纯沙眼衣原体宫颈感染的女性。在HeLa 229细胞中对沙眼衣原体进行定量分离，并将结果与针对该病原体的血清免疫球蛋白M和免疫球蛋白G抗体进行关联。我们发现，沙眼衣原体的定量培养可为评估获得性免疫反应的效果提供有意义的衡量标准。特别是，宫颈分泌物中针对沙眼衣原体的分泌型免疫球蛋白A抗体与该病原体从宫颈的清除呈显著负相关。提示免疫反应的这一组成部分可能调节该病原体的脱落。
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