TRIC 制剂与巨噬细胞的相互作用：对细胞溶酶体酶的影响。
Interactions of TRIC agents with macrophages: effects on lysosomal enzymes of the cell.
作者信息
Taverne J, Blyth W A, Ballard R C
出版信息
J Hyg (Lond). 1974 Apr;72(2):297-309. doi: 10.1017/s0022172400023512.
Abstract
TWO CHANGES WERE OBSERVED IN THE ACID PHOSPHATASE OF MACROPHAGES THAT HAD INGESTED INFECTIVE TRIC ORGANISMS
the proportion of extralysosomal enzyme rose, while the total amount in the cells fell. Both effects were directly related to the number of organisms ingested and increased with time. When macrophages were inoculated with more than 50 organisms per cell, changes were obvious within a few hours; with 2-10 organisms per cell changes were detectable only after 18 hr. or more. Enzyme appeared in the culture medium as the amount in the cells decreased. Ingestion of organisms killed by heat or treated with antibody did not induce such changes. In infected BHK-21 cells, no changes in acid phosphatase were detected at any stage of the developmental cycle of the organism.
摘要
在摄入感染性TRIC生物体的巨噬细胞酸性磷酸酶中观察到两个变化：溶酶体外酶的比例上升，而细胞内的总量下降。这两种效应都与摄入的生物体数量直接相关，并随时间增加。当每个细胞接种超过50个生物体时，几小时内变化就很明显；每个细胞接种2 - 10个生物体时，仅在18小时或更长时间后才能检测到变化。随着细胞内酶量的减少，酶出现在培养基中。摄入经加热杀死或用抗体处理的生物体不会诱导这种变化。在感染的BHK - 21细胞中，在生物体发育周期的任何阶段都未检测到酸性磷酸酶的变化。
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