噬菌体T5 DNA中所含单链中断的体内修复
In vivo repair of the single-strand interruptions contained in bacteriophage T5 DNA.
作者信息
Herman R C, Moyer R W
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):680-4. doi: 10.1073/pnas.71.3.680.
Abstract
Bacteriophage T5 is known to contain several unique single-strand interruptions in only one strand of the duplex DNA. Analysis of labeled parental phage DNA from infected Escherichia coli shows that these nicks are repaired in vivo to yield intact double-stranded molecules. Sealing begins at about 6 min after infection and is independent of DNA replication. Repair may be an ordered process that starts at a unique end of the molecule.
摘要
已知噬菌体T5仅在双链DNA的一条链中含有几个独特的单链中断。对来自受感染大肠杆菌的标记亲本噬菌体DNA的分析表明，这些切口在体内被修复，产生完整的双链分子。封口在感染后约6分钟开始，且与DNA复制无关。修复可能是一个从分子独特末端开始的有序过程。
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