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N5-methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells.

作者信息

Ashe H, Clark B R, Chu F, Hardy D N, Halpern B C, Halpern R M, Smith R A

出版信息

Biochem Biophys Res Commun. 1974 Mar 25;57(2):417-25. doi: 10.1016/0006-291x(74)90947-4.

DOI:10.1016/0006-291x(74)90947-4
PMID:4524503
Abstract
摘要

相似文献

1
N5-methyltetrahydrofolate: homocysteine methyltransferase activity in extracts from normal, malignant and embryonic tissue culture cells.
Biochem Biophys Res Commun. 1974 Mar 25;57(2):417-25. doi: 10.1016/0006-291x(74)90947-4.
2
New approach to antifolate treatment of certain cancers as demonstrated in tissue culture.组织培养中所展示的针对某些癌症的抗叶酸治疗新方法。
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3
[Activity of methionine synthetase (5-methyl-5,6,7,8-tetrahydrofolate: homocysteine methyltransferase) as a proliferation parameter in growing cells].[甲硫氨酸合成酶（5-甲基-5,6,7,8-四氢叶酸：同型半胱氨酸甲基转移酶）活性作为生长中细胞增殖参数的研究]
Acta Haematol. 1973;49(4):200-10. doi: 10.1159/000208406.
4
5-methyltetrahydrofolate homocysteine cobalamin methyltransferase in human bone marrow and its relationship to pernicious anemia.人骨髓中的5-甲基四氢叶酸同型半胱氨酸钴胺素甲基转移酶及其与恶性贫血的关系。
Arch Biochem Biophys. 1974 Dec;165(2):787-95. doi: 10.1016/0003-9861(74)90308-7.
5
Regulation of 5-methyltetrahydrofolate: homocysteine methyltransferase activity by methionine, vitamin B12, and folate in cultured baby hamster kidney cells.蛋氨酸、维生素B12和叶酸对培养的幼仓鼠肾细胞中5-甲基四氢叶酸：同型半胱氨酸甲基转移酶活性的调节
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2585-9. doi: 10.1073/pnas.70.9.2585.
6
The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.同型胱氨酸替代甲硫氨酸对培养的成年哺乳动物恶性及正常细胞存活的影响。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1133-6. doi: 10.1073/pnas.71.4.1133.
7
Effect of methionine replacement by homocystine in cultures containing both malignant rat breast carcinosarcoma (Walker-256) cells and normal adult rat liver fibroblasts.在同时含有恶性大鼠乳腺癌肉瘤（Walker - 256）细胞和正常成年大鼠肝脏成纤维细胞的培养物中，用同型半胱氨酸替代甲硫氨酸的效果。
In Vitro. 1975 Jan-Feb;11(1):14-9. doi: 10.1007/BF02615317.
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Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
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Induction of betaine: homocysteine methyltransferase in some murine cells cultured in vitro.体外培养的某些鼠细胞中甜菜碱：同型半胱氨酸甲基转移酶的诱导作用。
Biochim Biophys Acta. 1980 Oct 1;632(2):164-72. doi: 10.1016/0304-4165(80)90074-4.
10
B12 -- dependent methionine synthetase as a potential target for cancer chemotherapy.
Adv Enzyme Regul. 1976;14:187-205. doi: 10.1016/0065-2571(76)90013-3.

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Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment.
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Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.酶介导的血清 l-Met 耗竭通过多种机制阻断前列腺癌生长，而无全身毒性的证据。
Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13000-13011. doi: 10.1073/pnas.1917362117. Epub 2020 May 20.
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Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.致癌性 PI3K 通过胱氨酸-谷氨酸反向转运蛋白 xCT 促进乳腺癌细胞对蛋氨酸的依赖性。
Sci Signal. 2017 Dec 19;10(510):eaao6604. doi: 10.1126/scisignal.aao6604.
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De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.从头设计人类胱硫醚-γ-裂解酶用于系统性（L）-蛋氨酸耗竭癌症治疗。
ACS Chem Biol. 2012 Nov 16;7(11):1822-9. doi: 10.1021/cb300335j. Epub 2012 Sep 21.
7
Enhanced anticancer effect of vincristine with methionine infusion after methionine-depleting total parenteral nutrition in tumor-bearing rats.在荷瘤大鼠中，蛋氨酸耗竭的全胃肠外营养后输注蛋氨酸增强长春新碱的抗癌作用。
Jpn J Cancer Res. 1996 Feb;87(2):194-9. doi: 10.1111/j.1349-7006.1996.tb03158.x.
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Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial.蛋氨酸消耗性全胃肠外营养联合5-氟尿嘧啶对人胃癌的协同作用：一项随机、前瞻性临床试验。
Jpn J Cancer Res. 1995 May;86(5):484-9. doi: 10.1111/j.1349-7006.1995.tb03082.x.
9
Metabolism of 5-methyltetrahydrofolate by rats bearing the Walker 256 carcinosarcoma.携带Walker 256癌肉瘤大鼠对5-甲基四氢叶酸的代谢
Br J Cancer. 1982 Sep;46(3):440-3. doi: 10.1038/bjc.1982.222.
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Formation and utilization of methionine by rat liver cells in culture.培养的大鼠肝细胞中甲硫氨酸的形成与利用
In Vitro. 1983 Feb;19(2):134-40. doi: 10.1007/BF02621897.