高分子量核糖核酸中重复序列与单拷贝序列的散布情况。
Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight.
作者信息
Holmes D S, Bonner J
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1108-12. doi: 10.1073/pnas.71.4.1108.
Abstract
Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were interspersed within the same molecule. The present communication distinguishes between these possibilities and shows that a large proportion of nuclear RNA of high molecular weight consists of interspersed middle repetitive and single-copy sequences.
摘要
从大鼠腹水细胞中分离出的高分子量核RNA，长度约为15至30×10³个核苷酸，先前已证明其含有中度重复序列和单拷贝序列。然而，尚不清楚这些序列是位于不同的分子上，还是散布在同一分子内。本论文区分了这些可能性，并表明大部分高分子量核RNA由散布的中度重复序列和单拷贝序列组成。
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