David J C, Dairman W, Udenfriend S
Proc Natl Acad Sci U S A. 1974 May;71(5):1771-5. doi: 10.1073/pnas.71.5.1771.
Metabolism of tyrosine was examined in mice, some of which had been treated with an inhibitor of aromatic-L-amino-acid decarboxylase. The results of the study indicate that as the plasma and tissue levels of tyrosine are elevated, decarboxylation to tyramine becomes the predominant route of metabolism. At the highest dose of tyrosine used (1.5 g/kg), it was found that 42% of the administered dose was decarboxylated within 6 hr and only 11.5% was metabolized by the tyrosine aminotransferase pathway.
在小鼠中研究了酪氨酸的代谢，其中一些小鼠已用芳香族L-氨基酸脱羧酶抑制剂进行处理。研究结果表明，随着酪氨酸的血浆和组织水平升高，脱羧生成酪胺成为主要的代谢途径。在所用的最高酪氨酸剂量（1.5克/千克）下，发现在6小时内给予剂量的42%发生脱羧，只有11.5%通过酪氨酸转氨酶途径代谢。
