淋巴瘤细胞表面膜胆固醇水平的升高及其对腹水肿瘤发展的抑制作用。
Increase of cholesterol level in the surface membrane of lymphoma cells and its inhibitory effect on ascites tumor development.
作者信息
Inbar M, Shinitzky M
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):2128-30. doi: 10.1073/pnas.71.5.2128.
Abstract
An ascites form of malignant transformed lymphoma cells were treated in vitro with liposomes of 1:1 lecithin-cholesterol in order to increase the cholesterol level of the cell-surface membranes and thereby to increase the rigidity of the lipid layer. This treatment was found to inhibit the rate of killing by ascites tumor after intraperitoneal inoculation into adult mice of 10(4) and 10(5) treated cells per animal. With 10(3) treated cells per animal, full survival was observed up to 90 days after inoculation, whereas with the same number of untreated cells all infected mice died within 30 days after inoculation. An analogous treatment of the malignant lymphoma cells with liposomes of pure lecithin did not result in any appreciable inhibitory effect on the ascites tumor development in vivo, as initiated by inoculation of 10(5), 10(4), or 10(3) cells per animal.
摘要
将恶性转化的淋巴瘤细胞的腹水形式在体外用卵磷脂 - 胆固醇比例为1:1的脂质体处理，以提高细胞表面膜的胆固醇水平，从而增加脂质层的刚性。发现这种处理可抑制在成年小鼠腹腔内接种每只动物10⁴和10⁵个处理过的细胞后腹水肿瘤的杀伤速率。每只动物接种10³个处理过的细胞，接种后长达90天观察到完全存活，而接种相同数量的未处理细胞时，所有感染小鼠在接种后30天内死亡。用纯卵磷脂脂质体对恶性淋巴瘤细胞进行类似处理，对于每只动物接种10⁵、10⁴或10³个细胞引发的体内腹水肿瘤发展没有产生任何明显的抑制作用。
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