一种调节膜流动性的方法：磷脂、磷脂与磷脂-水模型生物膜的均相催化氢化作用。
A method for the modulation of membrane fluidity: homogeneous catalytic hydrogenation of phospholipids and phospholipids and phospholipid-water model biomembranes.
作者信息
Chapman D, Quinn P J
出版信息
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3971-5. doi: 10.1073/pnas.73.11.3971.
Abstract
The fatty acids associated with phospholipids of cell membranes, and particularly their degree of unsaturation, contribute to the fluidity of their structure and hance determine many of their biological properties. We describe a technique for modulating membrane fluidity which consists of hydrogenating the unsaturated double bonds of membrane phospholipids. This has been accomplished using a homogeneous catalyst. The process has been applied to phospholipids in organic solvents, to phospholipids dispersed as multibilayers in aqueous systems, and also to sonicated preparations of phospholipids arranged as single bilayer vesicles. Preliminary experiments have also been performed with biological membranes. These results indicate that the process of homogeneous catalysis for the modulation of lipid fluidity of biological cell membranes may have considerable future biological and biochemical application.
摘要
与细胞膜磷脂相关的脂肪酸，尤其是它们的不饱和程度，有助于其结构的流动性，并进而决定其许多生物学特性。我们描述了一种调节膜流动性的技术，该技术包括氢化膜磷脂的不饱和双键。这已通过使用均相催化剂得以实现。该过程已应用于有机溶剂中的磷脂、分散在水性体系中的多层磷脂，以及排列成单层囊泡的超声处理磷脂制剂。也已对生物膜进行了初步实验。这些结果表明，用于调节生物细胞膜脂质流动性的均相催化过程可能在未来具有相当多的生物学和生物化学应用。
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A method for the modulation of membrane fluidity: homogeneous catalytic hydrogenation of phospholipids and phospholipids and phospholipid-water model biomembranes.一种调节膜流动性的方法：磷脂、磷脂与磷脂-水模型生物膜的均相催化氢化作用。
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本文引用的文献
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