• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

促红细胞生成素对红系前体细胞体外集落生长的影响。

The effect of erythropoietin on colonial growth of erythroid precursor cells in vitro.

作者信息

Cooper M C, Levy J, Cantor L N, Marks P A, Rifkind R A

出版信息

Proc Natl Acad Sci U S A. 1974 May;71(5):1677-80. doi: 10.1073/pnas.71.5.1677.

DOI:10.1073/pnas.71.5.1677
PMID:4525458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388301/
Abstract

A method is described for the colonial growth, in semi-solid medium, of erythropoietin-responsive erythroid cell precursors. The erythroid cell precursors were isolated by immune hemolysis from fetal mouse liver. Both the number of precursor cells triggered to proliferate and differentiate, and the size of the erythropoietic colonies formed, are directly dependent upon the concentration of erythropoietin included in the culture.

摘要

本文描述了一种在半固体培养基中使促红细胞生成素反应性红系细胞前体进行集落生长的方法。通过免疫溶血从胎鼠肝脏中分离出红系细胞前体。被触发增殖和分化的前体细胞数量以及所形成的造血集落大小，都直接取决于培养物中促红细胞生成素的浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/388301/385a5c77a631/pnas00058-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/388301/14afa7ece338/pnas00058-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/388301/385a5c77a631/pnas00058-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/388301/14afa7ece338/pnas00058-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5655/388301/385a5c77a631/pnas00058-0101-a.jpg

相似文献

1
The effect of erythropoietin on colonial growth of erythroid precursor cells in vitro.促红细胞生成素对红系前体细胞体外集落生长的影响。
Proc Natl Acad Sci U S A. 1974 May;71(5):1677-80. doi: 10.1073/pnas.71.5.1677.
2
Purification of erythropoietin-responsive cells by immune hemolysis.通过免疫溶血法纯化促红细胞生成素反应性细胞。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1337-41. doi: 10.1073/pnas.69.6.1337.
3
Erythropoietin effects on fetal mouse erythroid cells. I. Cell population and hemoglobin synthesis.促红细胞生成素对胎鼠红细胞系细胞的影响。I. 细胞群体与血红蛋白合成。
J Cell Biol. 1971 Dec;51(3):585-95. doi: 10.1083/jcb.51.3.585.
4
Retrovirally-produced erythropoietin effectively induces differentiation and proliferation of J2E erythroid cells.逆转录病毒产生的促红细胞生成素能有效诱导J2E红系细胞的分化和增殖。
Growth Factors. 1993;9(2):87-97.
5
The regulation of hemoglobin synthesis in the fetal mouse.胎鼠血红蛋白合成的调控
Ser Haematol. 1971;4(3):7-22.
6
Globin messenger RNA activity in erythroid precursor cells and the effect of erythropoietin.红系前体细胞中的珠蛋白信使核糖核酸活性及促红细胞生成素的作用。
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3575-9. doi: 10.1073/pnas.69.12.3575.
7
Enhancement of erythroid colony growth in culture by hemin.
Exp Hematol. 1979 Jan;7(1):11-6.
8
Effects of human recombinant erythropoietin on differentiation and distribution of erythroid progenitor cells on murine medullary and splenic erythropoiesis during hypoxia and post-hypoxia.人重组促红细胞生成素对缺氧及缺氧后小鼠骨髓和脾脏红细胞生成过程中红系祖细胞分化和分布的影响。
In Vivo. 2001 Mar-Apr;15(2):125-32.
9
Evidence for proliferation of erythroid progenitor cells in the absence of added erythropoietin.在未添加促红细胞生成素的情况下红系祖细胞增殖的证据。
Exp Hematol. 1979 Aug;7(7):383-8.
10
Hemoglobin switching during murine embryonic development: evidence for two populations of embryonic erythropoietic progenitor cells.小鼠胚胎发育过程中的血红蛋白转换：两种胚胎红细胞生成祖细胞群体的证据。
Blood. 1986 Mar;67(3):716-21.

引用本文的文献

1
Induction of GD3/α1-adrenergic receptor/transglutaminase 2-mediated erythroid differentiation in chronic myelogenous leukemic K562 cells.诱导GD3/α1-肾上腺素能受体/转谷氨酰胺酶2介导的慢性粒细胞白血病K562细胞红系分化
Oncotarget. 2017 Aug 9;8(42):72205-72219. doi: 10.18632/oncotarget.20080. eCollection 2017 Sep 22.
2
Overexpression of miR-125a in myelodysplastic syndrome CD34+ cells modulates NF-κB activation and enhances erythroid differentiation arrest.骨髓增生异常综合征CD34+细胞中miR-125a的过表达调节NF-κB激活并增强红系分化阻滞。
PLoS One. 2014 Apr 1;9(4):e93404. doi: 10.1371/journal.pone.0093404. eCollection 2014.
3

本文引用的文献

1
Studies on erythropoiesis. XVI. Response to a single dose of erythropoietin in polycythemic mouse.红细胞生成的研究。十六、真性红细胞增多症小鼠对单剂量促红细胞生成素的反应。
J Lab Clin Med. 1961 Jan;57:65-72.
2
Erythropoiesis in the rat: differential rates of DNA synthesis and cell proliferation.大鼠中的红细胞生成：DNA合成和细胞增殖的差异速率。
Science. 1968 Dec 6;162(3858):1132-4. doi: 10.1126/science.162.3858.1132.
3
Erythropoietin effects on fetal mouse erythroid cells. I. Cell population and hemoglobin synthesis.促红细胞生成素对胎鼠红细胞系细胞的影响。I. 细胞群体与血红蛋白合成。
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
3-去氮杂胞苷 A（DZNep），一种 S-腺苷甲硫氨酸依赖性甲基转移酶抑制剂，可促进红细胞分化。
J Biol Chem. 2014 Mar 21;289(12):8121-34. doi: 10.1074/jbc.M114.548651. Epub 2014 Feb 3.
4
Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.Eos 在红细胞分化过程中负调控人 γ-珠蛋白基因转录。
PLoS One. 2011;6(7):e22907. doi: 10.1371/journal.pone.0022907. Epub 2011 Jul 28.
5
Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription.Birt-Hogg-Dubé 肿瘤抑制因子的缺失会导致凋亡抵抗，这是由于 TGFβ 介导的转录异常所致。
Oncogene. 2011 Jun 2;30(22):2534-46. doi: 10.1038/onc.2010.628. Epub 2011 Jan 24.
6
Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.AML1/ETO融合蛋白在干细胞中的表达可诱导小鼠发生骨髓增殖性疾病。
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15184-9. doi: 10.1073/pnas.0400751101. Epub 2004 Oct 11.
7
Differential regulation of SOCS genes in normal and transformed erythroid cells.正常和转化红细胞中SOCS基因的差异调控
Oncogene. 2003 May 22;22(21):3221-30. doi: 10.1038/sj.onc.1206381.
8
BCR/ABL inhibition by an escort/phosphatase fusion protein.一种护送蛋白/磷酸酶融合蛋白对BCR/ABL的抑制作用。
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12233-8. doi: 10.1073/pnas.210253497.
9
bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.bcl-x可防止原始红细胞和成熟末期终末红细胞的凋亡性细胞死亡。
J Exp Med. 1999 Jun 7;189(11):1691-8. doi: 10.1084/jem.189.11.1691.
10
Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.通过Hox-2.4同源盒基因对小鼠骨髓单核细胞、巨核细胞和肥大细胞祖细胞进行条件性永生化。
EMBO J. 1993 Oct;12(10):3835-46. doi: 10.1002/j.1460-2075.1993.tb06062.x.
J Cell Biol. 1971 Dec;51(3):585-95. doi: 10.1083/jcb.51.3.585.
4
Erythropoietin effects on fetal mouse erythroid cells. II. Nucleic acid synthesis and the erythropoietin-sensitive cell.促红细胞生成素对胎鼠红系细胞的作用。II. 核酸合成与促红细胞生成素敏感细胞
J Biol Chem. 1972 Feb 10;247(3):731-5.
5
Early stimulation of RNA synthesis by erythropoietin in cultures of erythroid precursor cells.促红细胞生成素对红系前体细胞培养物中RNA合成的早期刺激作用。
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3189-94. doi: 10.1073/pnas.70.11.3189.
6
Globin messenger RNA activity in erythroid precursor cells and the effect of erythropoietin.红系前体细胞中的珠蛋白信使核糖核酸活性及促红细胞生成素的作用。
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3575-9. doi: 10.1073/pnas.69.12.3575.
7
Purification of erythropoietin-responsive cells by immune hemolysis.通过免疫溶血法纯化促红细胞生成素反应性细胞。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1337-41. doi: 10.1073/pnas.69.6.1337.
8
Synthesis of macromolecules during induction of haemoglobin synthesis by erythropoietin.促红细胞生成素诱导血红蛋白合成过程中大分子的合成
J Mol Biol. 1969 May 28;42(1):31-41. doi: 10.1016/0022-2836(69)90484-7.
9
Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro.促红细胞生成素在体外诱导血红蛋白合成细胞集落的形成。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1542-6. doi: 10.1073/pnas.68.7.1542.