胚胎细胞表面识别的时间变化
Temporal changes in embryonal cell surface recognition.
作者信息
Gottlieb D I, Merrell R, Glaser L
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):1800-2. doi: 10.1073/pnas.71.5.1800.
Abstract
Plasma membranes have been prepared from optic tectum and neural retina of chick embryos. These membranes specifically inhibit the aggregation of homotypic cells. Plasma membranes prepared from each of these regions obtained from chick embryos at 7,8, and 9 days of development show specificity for homotypic cells of the same age and cross-react weakly with homotypic cells of different ages. Thus cell-surface recognition changes with age of development, and most of the cells in each region have a common cell-surface recognition specificity. Tectal cells react weakly with retinal cell membranes, but no inhibition of retinal cell aggregation by tectal cells has been noted.
摘要
已从鸡胚的视顶盖和神经视网膜制备了质膜。这些质膜能特异性抑制同型细胞的聚集。从发育7天、8天和9天的鸡胚的这些区域各自制备的质膜，对相同年龄的同型细胞具有特异性，而与不同年龄的同型细胞交叉反应较弱。因此，细胞表面识别随发育年龄而变化，并且每个区域的大多数细胞具有共同的细胞表面识别特异性。顶盖细胞与视网膜细胞膜反应较弱，但未观察到顶盖细胞对视网膜细胞聚集的抑制作用。
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