Lieberman M A, Glaser L
J Membr Biol. 1981;63(1-2):1-11. doi: 10.1007/BF01969440.
Cell-to-cell contact can result in a variety of changes in the cell's physiology. For different cell types, this may include both the initiation as well as the cessation of cell growth and changes in the state of differentiation. This review examines in detail one such phenomenon, density-dependent inhibition of growth, which is observed with many fibroblasts in culture. Data are summarized which demonstrate that the cessation of growth at high cell density is in part a consequence of cell-to-cell contact. An approach to the study of the molecular basis of this phenomenon is presented based on the demonstration that plasma membranes, when bound to sparse growing cells, mimic contact inhibition of growth. The present status of attempts to purify plasma membrane proteins responsible for this effect are summarized, and the properties of these membrane proteins are compared to those of previously described "soluble" proteins that inhibit cellular growth.
细胞间接触可导致细胞生理发生多种变化。对于不同的细胞类型，这可能包括细胞生长的起始和停止以及分化状态的改变。本综述详细研究了一种这样的现象，即培养中的许多成纤维细胞所观察到的密度依赖性生长抑制。总结了相关数据，这些数据表明高细胞密度下生长的停止部分是细胞间接触的结果。基于细胞膜与稀疏生长的细胞结合时模拟生长接触抑制的证明，提出了一种研究该现象分子基础的方法。总结了纯化负责这种效应的质膜蛋白的尝试的现状，并将这些膜蛋白的特性与先前描述的抑制细胞生长的“可溶性”蛋白的特性进行了比较。
