多种哺乳动物物种中脱氧核糖核酸切除修复与寿命之间的相关性。
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.
作者信息
Hart R W, Setlow R B
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2169-73. doi: 10.1073/pnas.71.6.2169.
Abstract
The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.
摘要
通过放射自显影法测定了七种物种在不同紫外线通量照射后的几个时间点成纤维细胞进行非预定DNA合成（一种切除修复的测量方法）的能力。[(3)H]胸苷的初始速率和最大掺入量均随物种寿命（鼩鼱、小鼠、大鼠、仓鼠、牛、大象、人类）的增加而增加。非预定DNA合成大致与寿命的对数成正比。
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