Bondavalli F, Lanteri S, Longobardi M, Schenone P
Farmaco Sci. 1979 Nov;34(11):945-51.
Lithium aluminum hydride reduction of exo-5,6-trimethylenenorbornan-2-one oxime gave in good yield exo-5,6-trimethylenenorbornan-2-endo-amine, from which a number of amides were prepared by reaction with acyl chlorides. Lithium aluminum hydride reduction of the above-mentioned amides afforded N-substituted exo-5,6-trimethylenenorbornan-2-endo-amines in good yields. Some amides showed CNS depressant and anti convulsant activity, and an amine convulsant activity in mice.
用氢化铝锂还原外型-5,6-亚甲基降冰片烷-2-酮肟，以良好产率得到外型-5,6-亚甲基降冰片烷-2-内型胺，通过与酰氯反应由其制备了许多酰胺。用氢化铝锂还原上述酰胺，以良好产率得到N-取代的外型-5,6-亚甲基降冰片烷-2-内型胺。一些酰胺在小鼠中显示出中枢神经系统抑制和抗惊厥活性，以及一种胺类惊厥活性。
