存在于人类白血病细胞核DNA和劳斯氏白血病病毒中的序列。
Sequences present in both human leukemic cell nuclear DNA and Rauscher leukemia virus.
作者信息
Baxt W G
出版信息
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2853-7. doi: 10.1073/pnas.71.7.2853.
Abstract
DNA synthesized by particulate fractions from human leukemic white blood cells has been subfractionated by hybridization to Rauscher leukemia virus 70S RNA followed by hydroxylapatite chromatography. The Rauscher-leukemia-virus-specific DNA fraction is shown to be complementary only to sequences present in the nuclear DNA of Balb/c mouse spleens infected by this virus and the nuclear DNA from human leukemic white blood cells, and not to sequences present in the nuclear DNA of normal Balb/c mouse spleens or the nuclear DNA of normal human white blood cells.
摘要
用人白血病白细胞的颗粒组分合成的DNA，先与劳氏肉瘤病毒70S RNA杂交，然后用羟基磷灰石层析进行亚分级分离。结果表明，劳氏肉瘤病毒特异性DNA组分仅与感染该病毒的Balb/c小鼠脾脏核DNA以及人白血病白细胞核DNA中的序列互补，而与正常Balb/c小鼠脾脏核DNA或正常人白细胞核DNA中的序列不互补。
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本文引用的文献
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J Natl Cancer Inst. 1962 Sep;29:515-43.
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Forms of deoxyribonucleic acid produced by virions of the ribonucleic acid tumor viruses.由核糖核酸肿瘤病毒的病毒粒子产生的脱氧核糖核酸形式。
J Virol. 1971 Jan;7(1):106-11. doi: 10.1128/JVI.7.1.106-111.1971.
3
Evolution of higher-organism DNA.高等生物DNA的进化
Q Rev Biophys. 1970 Aug;3(3):327-75. doi: 10.1017/s0033583500004765.
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Differences in murine leukaemia virus-specific DNA sequences in normal and malignant cells.正常细胞与恶性细胞中鼠白血病病毒特异性DNA序列的差异。
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Nuclear DNA sequences present in human leukemic cells and absent in normal leukocytes.人类白血病细胞中存在而正常白细胞中不存在的核DNA序列。
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