在大鼠急性实验性高血压中，阴离子转运抑制剂对脑内蛋白质外渗的预防作用

Prevention of protein extravasation in the brain by an anion transport inhibitor in acute experimental hypertension in rats.

作者信息

Hansson H A, Johansson B B

出版信息

Acta Physiol Scand. 1979 Apr;105(4):513-7. doi: 10.1111/j.1748-1716.1979.tb00116.x.

DOI:10.1111/j.1748-1716.1979.tb00116.x

Abstract

Acute experimental hypertension induces protein leakage in the brain. The protein is thought to be, at least to a great extent, transported through the endothelial cells by pinocytosis. An anion transport inhibitor, 4 acetamido-4-isothiocyano-stilbene-2,2'-disulfonic acid, markedly reduced adrenaline or bicuculline-induced leakage of 125IHSA and Evans blue-albumin in all areas of the rat brain. The preventive effect of dexamethasone was less pronounced and no effect was seen of haloperidol.

摘要

急性实验性高血压会导致大脑中蛋白质渗漏。这种蛋白质至少在很大程度上被认为是通过胞饮作用穿过内皮细胞运输的。一种阴离子转运抑制剂，4-乙酰氨基-4-异硫氰酸基芪-2,2'-二磺酸，能显著减少肾上腺素或荷包牡丹碱诱导的大鼠脑所有区域中125I标记的人血清白蛋白（125IHSA）和伊文思蓝-白蛋白的渗漏。地塞米松的预防作用不太明显，而氟哌啶醇则没有效果。

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Acta Neuropathol. 1980;51(1):33-8. doi: 10.1007/BF00688847.

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