亚油酸对肿瘤细胞生长的控制
Control of growth of a tumor cell by linoleic acid.
作者信息
Holley R W, Baldwin J H, Kiernan J A
出版信息
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3976-8. doi: 10.1073/pnas.71.10.3976.
Abstract
The growth of mouse myeloma XS 63.5 cells in cell culture is dependent on serum. Among the several growth factors present in serum, the lipid fraction is highly active. The growth factor(s) provided by the serum lipid fraction can be replaced by unsaturated fatty acids. If XS 63.5 cells are cultured in medium that is low in serum lipids, the cells become quiescent, with most of the cells in the G(1) (or G(0)) phase of the cell cycle. Addition of linoleic acid to such quiescent cells leads to reinitiation of DNA synthesis and growth.
摘要
小鼠骨髓瘤XS 63.5细胞在细胞培养中的生长依赖于血清。血清中存在的几种生长因子中，脂质部分具有高度活性。血清脂质部分提供的生长因子可被不饱和脂肪酸替代。如果将XS 63.5细胞培养在血清脂质含量低的培养基中，细胞会进入静止状态，大多数细胞处于细胞周期的G(1)（或G(0)）期。向此类静止细胞中添加亚油酸会导致DNA合成和生长重新开始。
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本文引用的文献
1
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Lipids. 1967 Jan;2(1):37-40. doi: 10.1007/BF02531998.
2
Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.多瘤病毒使仓鼠胚胎细胞发生肿瘤转化的步骤。
Proc Natl Acad Sci U S A. 1963 Feb 15;49(2):171-9. doi: 10.1073/pnas.49.2.171.
3
Observations on the silicic acid chromatography of the neutral lipides of rat liver, beef liver, and yeast.关于大鼠肝脏、牛肝脏和酵母中性脂质的硅酸色谱分析观察
J Biol Chem. 1958 Mar;231(1):493-503.
4
Measurement of polyunsaturated fatty acids.
Methods Biochem Anal. 1957;4:99-138. doi: 10.1002/9780470110201.ch3.
5
Cell microfluorometry: a method for rapid fluorescence measurement.细胞显微荧光测定法：一种快速荧光测量方法。
Science. 1969 Mar 14;163(3872):1213-4. doi: 10.1126/science.163.3872.1213.
6
Mouse myelomas and lymphomas in culture.培养中的小鼠骨髓瘤和淋巴瘤。
Exp Cell Res. 1970 Apr;60(1):61-77. doi: 10.1016/0014-4827(70)90489-1.
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A method for comparing effects of different synchronizing protocols on mammalian cell cycle traverse. The traverse perturbation index.一种比较不同同步化方案对哺乳动物细胞周期进程影响的方法。进程扰动指数。
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