Flake R H, Grant V
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3716-20. doi: 10.1073/pnas.71.9.3716.
It is shown for a continuous haploid model that the common standard assumptions used in calculating the cost of gene substitution, namely, large constant population size and small constant selective value, are unnecessary. Population size may fluctuate during the course of substitution without affecting the calculated total cost. The selective intensity does not need to be small and constant to give the standard result for substitution cost. Diploid models with multiple alleles are analyzed and contrasted with standard two-allele models in respect to calculation of substitution cost. The influence of population structure on the probability of occurrence of complete gene substitution is discussed on the basis of a numerical example. The robust nature of the cost-of-selection concept is examined in the light of a conservation principle.
对于一个连续单倍体模型的研究表明，在计算基因替代成本时所使用的常见标准假设，即恒定的大种群规模和小的恒定选择值，并非必要条件。在替代过程中种群规模可能会波动，但这并不影响所计算出的总成本。选择强度无需小且恒定就能得出替代成本的标准结果。分析了具有多个等位基因的二倍体模型，并在替代成本计算方面与标准双等位基因模型进行了对比。基于一个数值示例讨论了种群结构对完全基因替代发生概率的影响。根据一个守恒原理检验了选择成本概念的稳健性。
