重水会使多甲藻生物钟变慢：对“重水通过降低表观温度影响昼夜节律振荡”这一假说的验证。
Heavy water slows the Gonyaulax clock: a test of the hypothesis that D2O affects circadian oscillations by diminishing the apparent temperature.
作者信息
McDaniel M, Sulzman F M, Hastings J W
出版信息
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4389-91. doi: 10.1073/pnas.71.11.4389.
Abstract
In order to test the hypothesis that deuterium oxide acts in circadian systems by simulating a lower environmental temperature, we have examined the effects of D(2)O on Gonyaulax polyedra, where the period of the circadian rhythm of bioluminescent glow in constant environmental conditions is shorter at 16 degrees than at 22 degrees , and the phase of the glow peak relative to a light-dark cycle is advanced at 16 degrees relative to 22 degrees . Addition of low concentrations of D(2)O to Gonyaulax does not produce the same effects on period and phase as lowering the temperature; the free running period is lengthened and the phase is delayed. These results show that in the Gonyaulax rhythm, the effect of added D(2)O is not equivalent to lowering the temperature.
摘要
为了检验氧化氘通过模拟较低环境温度在昼夜节律系统中起作用这一假设，我们研究了重水（D₂O）对多甲藻的影响。在恒定环境条件下，多甲藻生物发光的昼夜节律周期在16摄氏度时比在22摄氏度时短，并且相对于明暗周期，发光峰值的相位在16摄氏度时相对于22摄氏度时提前。向多甲藻中添加低浓度的重水对周期和相位产生的影响与降低温度时不同；自由运行周期延长，相位延迟。这些结果表明，在多甲藻的节律中，添加重水的效果与降低温度并不等效。
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