Hafström L, Jönsson P E, Landberg T, Owman T, Sundkvist K
Am J Surg. 1979 Jun;137(6):757-62. doi: 10.1016/0002-9610(79)90088-6.
A retrospective analysis of the results of treatment of advanced rectal cancer of the pelvis with regional intraarterial infusion of 5-fluorouracil (5-FU) is reported. A special technic for positioning the catheters selectively in the internal iliac arteries justifies this analysis. Four patients with primary inextirpable rectal cancer and 10 patients with locally recurrent rectal cancer have been treated. No immediate mortality was noted. Relief of pain was noted in two-thirds of the patients. An objective tumor response was noted in three patients with locally recurrent disease. In one patient with primary inoperable cancer it was possible to extirpate the tumor after infusion therapy. An improvement in quality of life during the first 2 months after therapy was achieved in half of the patients as judged by their performance. Complications were not serious. Hematomas with infection were seen in one patient, two patients had septicemia, and three patients had transient oliguria. Transient thrombocytopenia was reported in two patients. The results indicate that infusion therapy produces a reasonable response such as palliation of pain. Only minor complications were seen and easily controlled. The advantages of infusion therapy are that it can be given in a reasonable time with only a short hospital stay.
本文报告了对盆腔晚期直肠癌采用5-氟尿嘧啶（5-FU）区域动脉内灌注治疗结果的回顾性分析。一种将导管选择性定位到髂内动脉的特殊技术为该分析提供了依据。已对4例原发性无法切除的直肠癌患者和10例局部复发性直肠癌患者进行了治疗。未观察到直接死亡情况。三分之二的患者疼痛得到缓解。3例局部复发性疾病患者出现了客观的肿瘤反应。1例原发性无法手术切除的癌症患者在灌注治疗后能够切除肿瘤。根据患者的表现判断，一半的患者在治疗后的前2个月生活质量得到改善。并发症并不严重。1例患者出现伴有感染的血肿，2例患者发生败血症，3例患者出现短暂性少尿。2例患者报告有短暂性血小板减少。结果表明，灌注治疗产生了合理的反应，如疼痛缓解。仅观察到轻微并发症且易于控制。灌注治疗的优点是可以在合理的时间内进行，且住院时间短。
