Wynne J W, Reynolds J C, Hood I, Auerbach D, Ondrasick J
Anesthesiology. 1979 Jul;51(1):11-9. doi: 10.1097/00000542-197907000-00004.
The instillation of gastric contents, 0.5 ml/kg (pH 4.3), containing small food particles into the left diaphragmatic lobe of the lungs of 49 rabbits caused severe aspiration pneumonitis. Administration of methylprednisolone, 30 mg/kg, intramuscularly, every eight hours for three days to 26 of the 49 rabbits did not alter the rate of roentgenographic resolution of the pneumonitis. Corticosteroids did decrease the fibroblastic response of the lung to the aspirate, but also interfered with healing of granulomatous lesions.
给49只家兔的左肺叶滴注0.5毫升/千克（pH值4.3）含有小食物颗粒的胃内容物，导致严重的吸入性肺炎。对49只家兔中的26只每八小时肌肉注射一次30毫克/千克甲泼尼龙，持续三天，这并未改变肺炎的X线片消退率。皮质类固醇确实降低了肺对吸入物的成纤维细胞反应，但也干扰了肉芽肿性病变的愈合。
