Montgomery P C, Rockey J H, Williamson A R
Proc Natl Acad Sci U S A. 1972 Jan;69(1):228-32. doi: 10.1073/pnas.69.1.228.
Rabbit antibody to dinitrophenyl hapten has been elicited by hyperimmunization with a bifunctional cyclic decapeptide antigen, di-dinitrophenyl-gramicidin-S. Examination of the induced antibody by isoelectric focusing, and Sipsian analysis of the haptenbinding data, demonstrated that di-dinitrophenyl-gramicidin-S was capable of stimulating and maintaining the production of a biosynthetically homogeneous antibody in the adult animal.
通过用双功能环状十肽抗原二硝基苯基短杆菌肽-S进行超免疫，已诱导出兔抗二硝基苯基半抗原抗体。通过等电聚焦对诱导产生的抗体进行检测，并对半抗原结合数据进行西普西安分析，结果表明二硝基苯基短杆菌肽-S能够刺激并维持成年动物体内生物合成均一抗体的产生。
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