Hood L, Lackland H, Eichman K, Kindt T J, Braun D G, Krause R M
Proc Natl Acad Sci U S A. 1969 Jul;63(3):890-6. doi: 10.1073/pnas.63.3.890.
Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneity when compared with preimmune light chains. Both of these related, but immunologically distinct, antigenic determinants select the same uncommon subpopulation of rabbit light chains.
轻链取自针对A组和C组链球菌群特异性碳水化合物的IgG兔抗体。对两种轻链制剂N端前三个位置存在的氨基酸替代物的分析表明，与免疫前轻链相比，氨基酸序列异质性受到明显限制。这两种相关但免疫上不同的抗原决定簇选择了兔轻链相同的罕见亚群。
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