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兔抗体轻链中的氨基酸序列限制

Amino acid sequence restriction in rabbit antibody light chains.

作者信息

Hood L, Lackland H, Eichman K, Kindt T J, Braun D G, Krause R M

出版信息

Proc Natl Acad Sci U S A. 1969 Jul;63(3):890-6. doi: 10.1073/pnas.63.3.890.

DOI:10.1073/pnas.63.3.890
PMID:5259770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223536/
Abstract

Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneity when compared with preimmune light chains. Both of these related, but immunologically distinct, antigenic determinants select the same uncommon subpopulation of rabbit light chains.

摘要

轻链取自针对A组和C组链球菌群特异性碳水化合物的IgG兔抗体。对两种轻链制剂N端前三个位置存在的氨基酸替代物的分析表明，与免疫前轻链相比，氨基酸序列异质性受到明显限制。这两种相关但免疫上不同的抗原决定簇选择了兔轻链相同的罕见亚群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/f6381e30c21c/pnas00109-0322-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/84f7fd896fac/pnas00109-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/cf252fc11481/pnas00109-0322-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/f6381e30c21c/pnas00109-0322-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/84f7fd896fac/pnas00109-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/cf252fc11481/pnas00109-0322-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75c7/223536/f6381e30c21c/pnas00109-0322-b.jpg

相似文献

1
Amino acid sequence restriction in rabbit antibody light chains.兔抗体轻链中的氨基酸序列限制
Proc Natl Acad Sci U S A. 1969 Jul;63(3):890-6. doi: 10.1073/pnas.63.3.890.
2
Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci.用C组链球菌免疫后诱导产生分子均一性的兔抗体。
J Exp Med. 1970 Jan 1;131(1):207-21. doi: 10.1084/jem.131.1.207.
3
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates.兔抗链球菌碳水化合物抗体个体抗原特异性的遗传
J Exp Med. 1971 Aug 1;134(2):532-52. doi: 10.1084/jem.134.2.532.
4
A partial amino acid sequence in the heavy chain of a rabbit antibody to group C streptococcal carbohydrate.兔抗C组链球菌碳水化合物抗体重链中的部分氨基酸序列。
Biochemistry. 1971 Jul 6;10(14):2753-61. doi: 10.1021/bi00790a016.
5
The amino acid sequence of a variable region of rabbit b4 chain from an anti-SIII antibody: comparison with light chains of the same sub-group from anti-A-variant carbohydrate antibodies.抗SIII抗体兔b4链可变区的氨基酸序列：与抗A变异碳水化合物抗体相同亚组轻链的比较。
Mol Immunol. 1979 Aug;16(8):589-95. doi: 10.1016/0161-5890(79)90122-6.
6
Rabbit antibody light chains: selective breeding narrows variability in framework and complementarity-determining residues.兔抗体轻链：选择性育种缩小了框架区和互补决定区残基的变异性。
Eur J Immunol. 1976 Aug;6(8):570-8. doi: 10.1002/eji.1830060809.
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Comparison of the amino acid sequences of the variable domains of two homogeneous rabbit antibodies to type III pneumococcal polysaccharide.两种针对III型肺炎球菌多糖的同源兔抗体可变区氨基酸序列的比较。
Biochem J. 1975 May;147(2):235-47. doi: 10.1042/bj1470235.
8
Restricted rabbit antibodies: amino acid sequences of rabbit H chains of allotype a1, a2, and a3 in the region 80 to 94.受限兔抗体：同种异型a1、a2和a3的兔重链在80至94区域的氨基酸序列。
J Immunol. 1973 Dec;111(6):1838-43.
9
[Immune response with monoclonal differentiation].[单克隆分化的免疫反应]
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Variable region correlates of group b allotypes: amino acid sequence studies of b9 L chains from homogeneous antibodies.B组同种异型的可变区相关性：来自同源抗体的b9轻链的氨基酸序列研究
Eur J Immunol. 1978 Jun;8(6):380-5. doi: 10.1002/eji.1830080603.

引用本文的文献

1
Allotype exclusion in uniform rabbit antibody to streptococcal carbohydrate.抗链球菌碳水化合物的兔单克隆抗体中的同种型排斥
J Exp Med. 1970 Feb;131(2):343-54. doi: 10.1084/jem.131.2.343.
2
Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci.用C组链球菌免疫后诱导产生分子均一性的兔抗体。
J Exp Med. 1970 Jan 1;131(1):207-21. doi: 10.1084/jem.131.1.207.
3
Electrophoretically homogeneous anti-DNP antibodies with restricted isoelectric points elicited in mice by immunization with the antigen papain-S-DNPL.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Studies on the chemical structure of the streptococcal cell wall. II. The composition of group C cell walls and chemical basis for serologic specificity of the carbohydrate moiety.链球菌细胞壁化学结构的研究。II. C群细胞壁的组成及碳水化合物部分血清学特异性的化学基础。
J Exp Med. 1962 Jan 1;115(1):49-62. doi: 10.1084/jem.115.1.49.
3
CHARACTERIZATION OF LAMPREY FIBRINOPEPTIDES.七鳃鳗纤维蛋白肽的特性分析
通过用抗原木瓜蛋白酶-S-DNPL免疫小鼠产生的具有受限等电点的电泳纯抗-DNP抗体。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):411-8. doi: 10.1073/pnas.66.2.411.
4
[Immune response with monoclonal differentiation].[单克隆分化的免疫反应]
Klin Wochenschr. 1971 Dec 1;49(23):1249-57. doi: 10.1007/BF01733077.
5
Immune response of rats to group A streptococcal vaccine.大鼠对A组链球菌疫苗的免疫反应。
Infect Immun. 1973 May;7(5):781-5. doi: 10.1128/iai.7.5.781-785.1973.
6
Homogeneous antibody elicited with dinitrophenyl-gramicidin-S (rabbit-isoelectric focusing).用二硝基苯基短杆菌肽-S引发的同源抗体（兔-等电聚焦）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):228-32. doi: 10.1073/pnas.69.1.228.
7
The emergence of antibodies with either identical or unrelated individual antigenic specificity during repeated immunizations with streptococcal vaccines.在用链球菌疫苗进行重复免疫期间，出现具有相同或不相关个体抗原特异性的抗体。
J Exp Med. 1970 Jun 1;131(6):1169-89. doi: 10.1084/jem.131.6.1169.
8
Idiotype expression and the inheritance of mouse antibody clones.独特型表达与小鼠抗体克隆的遗传
J Exp Med. 1973 Mar 1;137(3):603-21. doi: 10.1084/jem.137.3.603.
9
A comparison of the N-terminal amino acid sequences of early and late pools of anti-DNP and anti-DNP-p-aminobenzoylglutamate antibody light chains.抗二硝基苯酚（DNP）和抗对氨基苯甲酰谷氨酸-DNP抗体轻链早期和晚期库的N端氨基酸序列比较。
Immunology. 1978 May;34(5):853-61.
Biochem J. 1965 Mar;94(3):742-50. doi: 10.1042/bj0940742.
4
IMPROVED TECHNIQUE FOR THE PREPARATION OF STREPTOCOCCAL CELL WALLS.制备链球菌细胞壁的改良技术。
J Bacteriol. 1964 Oct;88(4):1198-200. doi: 10.1128/jb.88.4.1198-1200.1964.
5
Reduction of gamma-globulins.γ球蛋白减少
Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80.
6
Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.兔血清蛋白的同种异型。I. 免疫化学分析确定七种主要同种异型的个体差异
J Exp Med. 1960 Jul 1;112(1):107-24. doi: 10.1084/jem.112.1.107.
7
Structure of antibody molecules.抗体分子的结构。
Nature. 1967 Apr 29;214(5087):449-52 passim. doi: 10.1038/214449a0.
8
Hydrolysis of phenylthiohydantoins of amino acids.氨基酸苯硫代乙内酰脲的水解
Biochem Biophys Res Commun. 1964;14:399-403. doi: 10.1016/0006-291x(64)90075-0.
9
Rabbit antibodies to streptococcal carbohydrates. Influence of primary and secondary immunization and of possible genetic factors on the antibody response.抗链球菌碳水化合物的兔抗体。初次免疫和二次免疫以及可能的遗传因素对抗体反应的影响。
J Exp Med. 1969 Apr 1;129(4):809-30. doi: 10.1084/jem.129.4.809.
10
Chemical and immunochemical evidence for different classes of rabbit light polypeptide chains.不同类别的兔轻链多肽链的化学和免疫化学证据。
Proc Natl Acad Sci U S A. 1968 Jul;60(3):975-81. doi: 10.1073/pnas.60.3.975.