肿瘤细胞的免疫球蛋白合成：从IgM合成到IgG合成的克隆转变模型
Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis.
作者信息
Gordon J, Smith J L
出版信息
J Clin Pathol. 1980 Jun;33(6):539-54. doi: 10.1136/jcp.33.6.539.
Abstract
Tumour populations from two B cell neoplasms were investigated for their capacity to synthesise immunoglobulin in vitro. Neoplastic cells from a patient with chronic lymphocytic leukaemia and an IgG lambda paraproteinaemia co-expressed surface IgG lambda and IgM lambda and synthesised both IgG lambda and IgM lambda in short-term culture. In the second patient with non-Hodgkin's lymphoma, the neoplastic cells expressed surface IgM lambda but synthesised both IgM lambda and IgG lambda in vitro. The findings are discussed in terms of a model for the clonal switch from IgM to IgG synthesis.
摘要
对来自两种B细胞肿瘤的肿瘤群体进行了体外合成免疫球蛋白能力的研究。一名慢性淋巴细胞白血病合并IgG λ副蛋白血症患者的肿瘤细胞共表达表面IgG λ和IgM λ，并在短期培养中合成了IgG λ和IgM λ。在第二名非霍奇金淋巴瘤患者中，肿瘤细胞表达表面IgM λ，但在体外合成了IgM λ和IgG λ。根据从IgM合成向IgG合成的克隆转换模型对这些发现进行了讨论。
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