决定痘苗病毒株抗原性差异的一些因素。
Some factors determining differences in the antigenicity of vaccinia virus strains.
作者信息
Marennikova S S, Climiskjan K L, Senkman L S, Macevic G R
出版信息
Bull World Health Organ. 1972;46(2):159-63.
The causes determining differences in the antigenicity of different strains of vaccinia virus were investigated in rabbits. A relationship between the antigenicity of a strain and its capacity to multiply in immunized animals was established. Inactivated preparations of the viruses under investigation were capable of stimulating the production of virus neutralizing antibody in vaccinated rabbits. The virus showed the greatest accumulation and the longest persistence in animals vaccinated with the white clone Tashkent strain; similar results were obtained with the B-51 and Lister Institute strains. Strain EM-63 showed the smallest capacity to multiply.
在兔子身上研究了决定不同痘苗病毒株抗原性差异的原因。确定了毒株的抗原性与其在免疫动物体内增殖能力之间的关系。所研究病毒的灭活制剂能够刺激接种疫苗的兔子产生病毒中和抗体。在接种了塔什干白色克隆株的动物体内，病毒积累最多且持续时间最长；B - 51株和李斯特研究所株也得到了类似结果。EM - 63株的增殖能力最小。
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