尖孢镰刀菌萎蔫专化型菌株将安圭定（4,15-二乙酰氧基-3-蒈烯醇）转化为3-乙酰氧基-4,15-蒈二烯二醇。
Production of 3-acetoxyscirpene-4,15-diol from anguidine (4,15-diacetoxyscirpene-3-ol) by Fusarium oxysporum f.sp. vasinfectum.
作者信息
Claridge C A, Schmitz H
出版信息
Appl Environ Microbiol. 1979 Apr;37(4):693-6. doi: 10.1128/aem.37.4.693-696.1979.
Abstract
Growing cells of Fusarium oxysporum f.sp. vasinfectum (ATCC 7808) formed 3-acetoxyscirpene-4,15-diol from anguidine (4,15-diacetoxyscirpene-3-ol) by way of the intermediates triacetoxyscirpene, 3,4-diacetoxyscirpene-15-ol and 3,15-diacetoxyscirpene-4-ol. The new 3-acetoxy analog was found to be less active than anguidine and the other monoacetoxy derivatives when tested against a series of fungal strains and against HeLa cells in vitro.
摘要
尖孢镰刀菌西瓜专化型（ATCC 7808）的生长细胞通过三乙酰氧基刺蒎烯、3,4-二乙酰氧基刺蒎烯-15-醇和3,15-二乙酰氧基刺蒎烯-4-醇中间体，由安圭定（4,15-二乙酰氧基刺蒎烯-3-醇）形成3-乙酰氧基刺蒎烯-4,15-二醇。当在体外针对一系列真菌菌株和HeLa细胞进行测试时，发现新的3-乙酰氧基类似物的活性低于安圭定和其他单乙酰氧基衍生物。
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