Singh R K, Ben-Aziz A, Britton G, Goodwin T W
Biochem J. 1973 Mar;132(3):649-52. doi: 10.1042/bj1320649.
Neurosporene replaces spheroidene and hydroxyspheroidene as the main carotenoid in Rhodopseudomonas spheroides and Rhodopseudomonas gelatinosa grown in the presence of nicotine. On removal of the nicotine, spheroidene and hydroxyspheroidene are formed at the expense of the accumulated neurosporene. This shows that nicotine inhibits introduction of the C-1 tertiary hydroxyl groups, and supports the postulated pathway neurosporene-->spheroidene-->hydroxyspheroidene.
在尼古丁存在的情况下生长的球形红假单胞菌和明胶红假单胞菌中,神经孢红素取代了球形烯和羟基球形烯成为主要类胡萝卜素。去除尼古丁后,球形烯和羟基球形烯以积累的神经孢红素为代价而形成。这表明尼古丁抑制了C-1叔羟基的引入,并支持了假定的神经孢红素→球形烯→羟基球形烯的途径。