球形红假单胞菌中的类胡萝卜素生物合成。S-腺苷甲硫氨酸作为球形烯和球形烯酮生物合成中的甲基化剂。
Carotenoid biosynthesis in Rhodopseudomonas spheroides. S-adenosylmethionine as the methylating agent in the biosynthesis of spheroidene and spheroidenone.
作者信息
Singh R K, Britton G, Goodwin T W
出版信息
Biochem J. 1973 Oct;136(2):413-9. doi: 10.1042/bj1360413.
Abstract
[methyl-(14)C]Methionine and S-adenosyl[methyl-(14)C]methionine were incorporated into the methoxycarotenoids spheroidene and spheroidenone by Rhodopseudomonas spheroides. The incorporation was greatly enhanced in the presence of lysozyme. On degradation of labelled spheroidene by hydriodic acid, the (14)C label was recovered in methyl iodide. Degradation of spheroidenone by reduction and allylic dehydration and demethylation of the reduction product gave a mixture of unlabelled carotenoid hydrocarbons, including 3,4-didehydrolycopene and 3,4-didehydro-7',8'-dihydrolycopene. The label from [methyl-(14)C]methionine and S-adenosyl[methyl-(14)C]methionine was located specifically in the methoxy group of spheroidene and spheroidenone. The biosynthesis of methoxycarotenoids in Rps. spheroides involves methylation of the tertiary hydroxyl groups of intermediates with S-adenosylmethionine.
摘要
球形红假单胞菌可将[甲基-(14)C]甲硫氨酸和S-腺苷[甲基-(14)C]甲硫氨酸掺入到甲氧基类胡萝卜素类球烯和类球酮中。在溶菌酶存在的情况下，掺入量大大增加。用氢碘酸降解标记的类球烯时，(14)C标记物在碘甲烷中回收。通过还原、烯丙基脱水以及还原产物的去甲基化作用降解类球酮，得到了未标记的类胡萝卜素烃混合物，包括3,4-二脱氢番茄红素和3,4-二脱氢-7',8'-二氢番茄红素。[甲基-(14)C]甲硫氨酸和S-腺苷[甲基-(14)C]甲硫氨酸中的标记物特异性地位于类球烯和类球酮的甲氧基中。球形红假单胞菌中甲氧基类胡萝卜素的生物合成涉及中间体的叔羟基与S-腺苷甲硫氨酸的甲基化反应。
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