组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。IV. 免疫反应（Ir）基因在由该基因控制的反应中对淋巴细胞相互作用的控制作用。
Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.
作者信息
Katz D H, Hamaoka T, Dorf M E, Maurer P H, Benacerraf B
出版信息
J Exp Med. 1973 Sep 1;138(3):734-9. doi: 10.1084/jem.138.3.734.
Abstract
In the present study we have asked the question of whether F(1) carrier-primed T cells can serve as helper cells for either or both parental B cells when (a) the carrier molecule employed is under genetic control such that one parental strain is a responder and the other is a nonresponder, and (b) the determinant specificity of the parental B cells being assessed is not under genetic control and bears no relationship to the specificity of the carrier molecule. Utilizing the system of immune response gene control of responses to the terpolymer L-glutamic acid-L-lysine-L-tyrosine (GLT) to which A strain mice (H-2(a)) are nonresponders, whereas BALB/c (H-2(d)) and (BALB/c x A)F(1) hybrids (CAF(1)) are responders, these studies demonstrate that GLT-primed T cells of CAF(1) donors can provide for responder BALB/c, but not for nonresponder A/J, the required stimulus for the anti-DNP responses of DNP-specific B cells of these respective parental strains to the DNP conjugate of GLT. The implications of these findings for Ir gene function in physiologic T-B cell interactions are discussed in detail.
摘要
在本研究中，我们提出了以下问题：当（a）所采用的载体分子受基因控制，使得一个亲本品系是反应者而另一个是无反应者，且（b）所评估的亲代B细胞的决定簇特异性不受基因控制且与载体分子的特异性无关时，F(1)载体致敏T细胞是否能作为亲代B细胞一方或双方的辅助细胞。利用对三聚物L-谷氨酸-L-赖氨酸-L-酪氨酸（GLT）的免疫反应基因控制系统，其中A品系小鼠（H-2(a)）是无反应者，而BALB/c（H-2(d)）及（BALB/c×A）F(1)杂种小鼠（CAF(1)）是反应者，这些研究表明，CAF(1)供体的GLT致敏T细胞能够为反应性的BALB/c提供所需刺激，以促使这些亲代品系的DNP特异性B细胞对GLT的DNP偶联物产生抗DNP反应，但不能为无反应性的A/J提供这种刺激。本文详细讨论了这些发现对生理T-B细胞相互作用中Ir基因功能的意义。
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