Emerson B B, Smith A L, Harding A L, Smith D H
J Pediatr. 1975 Apr;86(4):617-20. doi: 10.1016/s0022-3476(75)80166-1.
One hundred and one strains of Hemophilus influenzae type b isolated at the Children's Hospital Medical Center from blood or CSF and 18 strains known to be resistant to ampicillin of which 17 were supplied to us by others were tested for their sensitivity to 17 antibiotics. Two groups were defined according to their sensitivity to ampicillin. When 10-3 bacteria were applied, 18 strains isolated from patients with ampicillin treatment failures had a median minimum inhibitory concentrations of 3.1 mug/ml. At 10-6 bacteria the median MIC for the resistant strains increased 512-fold, whereas the sensitive strains increased two-fold. The most active antibiotics against sensitive and resistant strains were rifampin, chloramphenicol, gentamicin, rosamycin, and erythromycin with MICs ranging from 0.2-0.8 mug/ml at 10-3 bacteria and from 0.2-1.6 mug/ml at 10-6.
从儿童医院医疗中心的血液或脑脊液中分离出101株b型流感嗜血杆菌，并对18株已知对氨苄西林耐药的菌株（其中17株由其他机构提供给我们）进行了17种抗生素的敏感性测试。根据它们对氨苄西林的敏感性定义了两组。当接种10⁻³个细菌时，从氨苄西林治疗失败患者中分离出的18株菌株的最低抑菌浓度中位数为3.1μg/ml。在接种10⁻⁶个细菌时，耐药菌株的最低抑菌浓度中位数增加了512倍，而敏感菌株增加了两倍。对敏感和耐药菌株最有效的抗生素是利福平、氯霉素、庆大霉素、罗沙霉素和红霉素，在接种10⁻³个细菌时最低抑菌浓度范围为0.2 - 0.8μg/ml，在接种10⁻⁶个细菌时为0.2 - 1.6μg/ml。
