氨苯砜所致溶血性贫血的研究。I.高铁血红蛋白生成及葡萄糖-6-磷酸脱氢酶活性与氨苯砜剂量的相关性

Studies on dapsone induced haemolytic anaemia. I. Methaemoglobin production and G-6-PD activity in correlation with dapsone dosage.

作者信息

Manfredi G, De Panfilis G, Zampetti M, Allegra F

出版信息

Br J Dermatol. 1979 Apr;100(4):427-32. doi: 10.1111/j.1365-2133.1979.tb01644.x.

DOI:10.1111/j.1365-2133.1979.tb01644.x

Abstract

The present study was undertaken on the hypothesis that methaemoglobin production and haemolytic anaemia following dapsone administration could be ascribed to an impairment of glucose-6-phosphate dehydrogenase-enzymatic activity. Analysis of the kinetic parameters of the G-6-PD (Vmax and KM) was performed in ten patients, normal with respect to G-6-PD, suffering from various dermatoses. It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methaemoglobin production and anaemia make reasonable the hypothesis that a toxic dapsone derivative (DDS-NHOH) could be responsible for the methaemoglobin formation and the haemolytic anaemia.

摘要

本研究基于以下假设开展

服用氨苯砜后高铁血红蛋白生成及溶血性贫血可能归因于葡萄糖-6-磷酸脱氢酶活性受损。对10名患有各种皮肤病、葡萄糖-6-磷酸脱氢酶（G-6-PD）正常的患者进行了G-6-PD动力学参数（Vmax和KM）分析。得出的结论是，氨苯砜治疗后的溶血性贫血并非由于该酶的功能受损。氨苯砜剂量、高铁血红蛋白生成与贫血之间的密切关系使得以下假设合理：一种有毒的氨苯砜衍生物（DDS-NHOH）可能是高铁血红蛋白形成及溶血性贫血的原因。