补体在体内诱导抗体产生中的作用。眼镜蛇因子和其他C3反应剂对胸腺依赖性和非胸腺依赖性抗体反应的影响。
Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses.
作者信息
Pepys M B
出版信息
J Exp Med. 1974 Jul 1;140(1):126-45. doi: 10.1084/jem.140.1.126.
Abstract
In an in vivo study in mice, suppression by the C3-cleaving protein of cobra venom (CoF), and other C3-reactive agents (zymosan, aggregated IgG, anti-C3 antibodies, and type III pneumococcal polysaccharide) of the thymus-dependent antibody responses to sheep erythrocytes, ovalbumin, and human IgG was demonstrated. The thymus-independent antibody response to polyvinyl-pyrrolidone was however unaffected by CoF. These and other published observations suggest that there may be a requirement for functional C3 in induction of thymus-dependent but not thymus-independent antibody production. A model for the role of C3 in lymphocyte cooperation is proposed based on these data analyzed in the light of existing knowledge of this process. It is postulated that fixed C3 interacting with macrophage See PDF for Structure and B-cell C3 receptors might enhance or facilitate T-dependent presentation of antigen to B cells.
摘要
在一项对小鼠的体内研究中，已证实眼镜蛇毒的C3裂解蛋白（CoF）以及其他C3反应剂（酵母聚糖、聚合IgG、抗C3抗体和III型肺炎球菌多糖）可抑制对绵羊红细胞、卵清蛋白和人IgG的胸腺依赖性抗体反应。然而，对聚乙烯吡咯烷酮的非胸腺依赖性抗体反应不受CoF影响。这些以及其他已发表的观察结果表明，在诱导胸腺依赖性而非非胸腺依赖性抗体产生过程中，可能需要功能性C3。基于根据该过程的现有知识分析的这些数据，提出了一个C3在淋巴细胞协作中作用的模型。据推测，与巨噬细胞（结构见PDF）和B细胞C3受体相互作用的固定C3可能增强或促进T细胞依赖性抗原向B细胞的呈递。
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Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses.补体在体内诱导抗体产生中的作用。眼镜蛇因子和其他C3反应剂对胸腺依赖性和非胸腺依赖性抗体反应的影响。
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