核物质在免疫信息传递中的作用。II. 核有丝分裂原的作用方式。
The role of nuclear material in the transfer of immunological information. II. The mode of action of nuclear mitogen.
作者信息
Lewis C M, Pegrum G D
出版信息
Immunology. 1974 Nov;27(5):929-39.
Nuclei from lymphocytes which have been stimulated with phyto-haemagglutinin (PHA) or concanavalin A (Con A) are capable of stimulating both T and B lymphocytes. The basis of the mitogenic properties of these nuclei has been investigated in more detail. Mitogen has been labelled with I and the various constituents of the nuclei (RNA, DNA and protein) have also been labelled in an attempt to determine their cellular localization during stimulation. The effects of competing sugars and inhibitory antisera have also been examined. The results of the experiments suggest that the mitogenic effects of nuclei may result from concentration or complexing of PHA or Con A either in the nucleus or on the nuclear membrane.
用植物血凝素（PHA）或刀豆球蛋白A（Con A）刺激过的淋巴细胞的细胞核能够刺激T淋巴细胞和B淋巴细胞。对这些细胞核的促有丝分裂特性的基础进行了更详细的研究。用碘标记有丝分裂原，并且还对细胞核的各种成分（RNA、DNA和蛋白质）进行了标记，试图确定它们在刺激过程中的细胞定位。还研究了竞争性糖类和抑制性抗血清的作用。实验结果表明，细胞核的促有丝分裂作用可能是由于PHA或Con A在细胞核内或核膜上的浓缩或复合所致。
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