分裂细胞以及用促细胞分裂剂固化后的淋巴细胞表面膜变化。
Lymphocyte surface membrane changes in dividing cells and following regidification with mitogens.
作者信息
Lewis C M, Pegrum G D
出版信息
Immunology. 1977 Mar;32(3):265-9.
Iodination of surface membrane protein has allowed the dynamics of lymphocyte surface membrane protein to be examined. A comparison has been made between the rate of membrane turnover in fresh peripheral blood lymphocytes and lymphocytes in other states. When receptor redistribution is inhibited with high concentrations of mitogens, 'rigidification' of the membrane occurs and protein turnover is very much reduced. Loss of surface membrane protein is also much slower in lymphocytes which have been stimulated with mitogens and are undergoing active DNA synthesis. It is thought that these observations may relate to immunological inactivity and may have implications for pathological unresponsiveness.
表面膜蛋白的碘化作用使得淋巴细胞表面膜蛋白的动力学得以研究。已对新鲜外周血淋巴细胞和处于其他状态的淋巴细胞的膜更新速率进行了比较。当用高浓度的促细胞分裂剂抑制受体重新分布时，膜会发生“僵化”，蛋白质更新也会大大减少。在用促细胞分裂剂刺激并正在进行活跃DNA合成的淋巴细胞中，表面膜蛋白的损失也慢得多。据认为，这些观察结果可能与免疫无活性有关，并且可能对病理性无反应性有影响。
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