用于口服免疫的霍乱弧菌减毒重组菌株。
Attenuated recombinant strains of Vibrio cholerae for oral immunization.
作者信息
Srivastava B S, Sinha V B, Srivastava R
出版信息
Bull World Health Organ. 1979;57(4):649-54.
Abstract
Two attenuated strains of Vibrio cholerae, CD1 and CD3, have been isolated that have remained stable since 1976. These strains are motile, adhere to and multiply in rabbit intestine, and colonize the gut of infant mice for 6-7 days. Both strains are antigenic and provide protection to challenge in the mouse protection test and in the rabbit ileal loop model. Because of their ability to adhere to and colonize the gut, and since they are antigenic, strains CD1 and CD3 have the potentiality of oral vaccines.
摘要
已分离出两株霍乱弧菌减毒株，CD1和CD3，自1976年以来一直保持稳定。这些菌株具有运动性，能在兔肠道内黏附并繁殖，并在幼鼠肠道内定殖6至7天。两株菌株都具有抗原性，在小鼠保护试验和兔回肠袢模型中能提供针对攻击的保护作用。由于它们具有黏附并定殖于肠道的能力，且具有抗原性，CD1和CD3菌株有作为口服疫苗的潜力。
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Attenuation of virulence by P and V plasmids in Vibrio cholerae: strains suitable for oral immunization.霍乱弧菌中P质粒和V质粒对毒力的减弱作用：适用于口服免疫的菌株
Bull World Health Organ. 1979;57(4):643-7.
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