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Modified messenger ribonucleic acid release from isolated hepatic nuclei after inhibition of polyadenylate formation.多聚腺苷酸形成受抑制后，从分离的肝细胞核中释放出的修饰信使核糖核酸
Biochem J. 1974 Apr;139(1):191-6. doi: 10.1042/bj1390191.
2
The action of cordycepin on nascent nuclear RNA and poly(A) synthesis in regenerating liver.虫草素对再生肝脏中新生核RNA和多聚腺苷酸（poly(A)）合成的作用。
Biochim Biophys Acta. 1976 Jan 19;418(2):160-6. doi: 10.1016/0005-2787(76)90065-4.
3
The effect of tryptrophan on nucleocytoplasmic translocation of RNA in rat liver.色氨酸对大鼠肝脏中RNA核质转运的影响。
Biochim Biophys Acta. 1977 Jan 3;474(1):117-28. doi: 10.1016/0005-2787(77)90219-2.
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Regulated transport of messenger ribonucleic acid from isolated liver nuclei by nucleic acid binding proteins.信使核糖核酸通过核酸结合蛋白从分离的肝细胞核进行的调节转运。
Biochemistry. 1981 May 26;20(11):3253-62. doi: 10.1021/bi00514a042.
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Inhibition of ribonucleic acid efflux from isolated SV40-3T3 cell nuclei by 3'-deoxyadenosine (cordycepin).3'-脱氧腺苷（虫草素）对从分离的SV40-3T3细胞核中流出核糖核酸的抑制作用。
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Selective inhibition of initial polyadenylation in isolated nuclei by low levels of cordycepin 5"-triphosphate.低水平的虫草素5′-三磷酸对分离细胞核中初始多聚腺苷酸化的选择性抑制作用。
Biochim Biophys Acta. 1977 Apr 4;475(3):548-52. doi: 10.1016/0005-2787(77)90069-7.
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Effect of tryptophan on polyriboadenylic acid and polyadenylic acid-messenger ribonucleic acid in rat liver.色氨酸对大鼠肝脏中聚核糖核酸和聚腺苷酸-信使核糖核酸的影响。
Lab Invest. 1976 Jan;34(1):77-85.
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Effect of cordycepin on ribosome formation and enzyme induction in rat liver.虫草素对大鼠肝脏核糖体形成及酶诱导的影响。
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Elongation of the polyadenylate segment of messenger RNA in the cytoplasm of mammalian cells.哺乳动物细胞细胞质中信使核糖核酸多聚腺苷酸片段的延伸。
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Isolation and Properties of Nuclei from Control and Auxin-treated Soybean Hypocotyl.从对照和生长素处理的大豆下胚轴中分离细胞核。
Plant Physiol. 1975 Jul;56(1):78-82. doi: 10.1104/pp.56.1.78.
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Nuclear ribonucleoprotein release and nucleoside triphosphatase activity are inhibited by antibodies directed against one nuclear matrix glycoprotein.针对一种核基质糖蛋白的抗体可抑制核糖核蛋白释放和核苷三磷酸酶活性。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2285-9. doi: 10.1073/pnas.80.8.2285.
3
Effect of cytosol on transport of RNA in vitro during cardiac hypertrophy.心肌肥大时胞质溶胶对体外RNA转运的影响。
Biochem J. 1983 Feb 1;209(2):285-90. doi: 10.1042/bj2090285.
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A comparative study of the early effects of phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat liver.苯巴比妥和3-甲基胆蒽对大鼠肝脏核糖核酸合成与转运早期影响的比较研究。
Biochem J. 1980 Jan 15;186(1):81-7. doi: 10.1042/bj1860081.
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Nutritional control of protein synthesis. Studies relating to tryptophan-induced stimulation of nucleocytoplasmic translocation of mRNA in rat liver.蛋白质合成的营养调控。关于色氨酸诱导大鼠肝脏mRNA核质转运刺激作用的研究。
Am J Pathol. 1984 Nov;117(2):298-309.
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Inflammation-associated events in liver nuclei during acute-phase reaction.急性期反应期间肝细胞核内的炎症相关事件。
Inflammation. 1986 Jun;10(2):109-17. doi: 10.1007/BF00915993.
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The influence of hypertonic NaCl on nucleocytoplasmic translocation of RNA in the rat liver.高渗氯化钠对大鼠肝脏中RNA核质转运的影响。
Am J Pathol. 1986 Jun;123(3):577-84.
8
Nucleocytoplasmic RNA transport.核质RNA转运
Mol Cell Biochem. 1985 Jul;67(2):87-99. doi: 10.1007/BF02370167.
9
Role of cytosol in the stimulation of RNA transport in vitro during cardiac hypertrophy in rats.胞质溶胶在大鼠心肌肥大过程中体外刺激RNA转运中的作用。
Biochem J. 1990 Apr 1;267(1):133-40. doi: 10.1042/bj2670133.
10
Ribonucleic acid synthesis in isolated rat liver nuclei under conditions of ribonucleic acid processing and transport.在核糖核酸加工和转运条件下分离的大鼠肝细胞核中的核糖核酸合成。
Biochem J. 1975 May;147(2):193-7. doi: 10.1042/bj1470193.

本文引用的文献

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The influence of chain length and base composition on the specific association of oligoribonucleotides with denatured deoxyribonucleic acid.链长和碱基组成对寡核糖核苷酸与变性脱氧核糖核酸特异性结合的影响。
J Biol Chem. 1969 Mar 25;244(6):1576-81.
2
Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship.海拉细胞异质性核RNA和快速标记的多核糖体RNA中的聚腺苷酸序列：前体关系的可能证据。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1336-40. doi: 10.1073/pnas.68.6.1336.
3
A polynucleotide segment rich in adenylic acid in the rapidly-labeled polyribosomal RNA component of mouse sarcoma 180 ascites cells.在小鼠肉瘤180腹水细胞快速标记的多核糖体RNA组分中富含腺苷酸的多核苷酸片段。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1331-5. doi: 10.1073/pnas.68.6.1331.
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Messenger and heterogeneous nuclear RNA in HeLa cells: differential inhibition by cordycepin.HeLa细胞中的信使核糖核酸和不均一核核糖核酸：虫草素的差异抑制作用
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1878-85. doi: 10.1073/pnas.67.4.1878.
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Properties of nuclear RNA in sea urchin embryos.海胆胚胎中核RNA的特性。
Proc Natl Acad Sci U S A. 1969 Jan;62(1):186-93. doi: 10.1073/pnas.62.1.186.
6
Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA.聚腺苷酸序列：在核RNA转变为信使RNA过程中的作用
Science. 1971 Oct 29;174(4008):507-10. doi: 10.1126/science.174.4008.507.
7
Regulated transport of ribosomal subunits from regenerating rat liver nuclei in a cell-free system.无细胞体系中大鼠再生肝细胞核核糖体亚基的调控转运
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Transport of informosomes from isolated nuclei of regenerating rat liver.信息体从再生大鼠肝脏分离细胞核的转运
Biochem Biophys Res Commun. 1972 Sep 5;48(5):1259-65. doi: 10.1016/0006-291x(72)90847-9.
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Regulation of ribosome formation in regenerating rat liver.再生大鼠肝脏中核糖体形成的调控
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10
Nascent catalase and its messenger RNA on rat liver polyribosomes.大鼠肝脏多核糖体上的新生过氧化氢酶及其信使核糖核酸
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多聚腺苷酸形成受抑制后，从分离的肝细胞核中释放出的修饰信使核糖核酸

Modified messenger ribonucleic acid release from isolated hepatic nuclei after inhibition of polyadenylate formation.

作者信息

Schumm D E, Webb T E

出版信息

Biochem J. 1974 Apr;139(1):191-6. doi: 10.1042/bj1390191.

DOI:10.1042/bj1390191
PMID:4549426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166266/
Abstract

Treatment of rats with Cordycepin (3'-deoxyadenosine), an inhibitor of nuclear poly(A) synthesis, selectively decreased the energy and cytosol-dependent release of a portion of the mRNA species from the isolated hepatic nuclei in a cell-free system by approximately 40%. An analysis of the differential binding of the transported mRNA containing poly(A) tracts to nitrocellulose filters, and to cellulose or poly(U)-Sepharose columns suggested that the poly(A) tracts in the mRNA transported from the isolated hepatic nuclei of Cordycepin-treated rats, are decreased in size. This size decrease was confirmed through an analysis of the average size of the poly(A) tracts, released from the messengers by ribonuclease activity, on sucrose density gradients.

摘要

用核多聚腺苷酸合成抑制剂虫草素（3'-脱氧腺苷）处理大鼠，在无细胞体系中，可使从分离的肝细胞核中释放的一部分mRNA种类的能量和胞质溶胶依赖性释放选择性降低约40%。对含有多聚腺苷酸尾的转运mRNA与硝酸纤维素滤膜、纤维素或聚尿苷酸-琼脂糖柱的差异结合分析表明，从经虫草素处理的大鼠分离肝细胞核转运的mRNA中的多聚腺苷酸尾大小减小。通过对核糖核酸酶活性从信使中释放的多聚腺苷酸尾在蔗糖密度梯度上的平均大小分析，证实了这种大小的减小。