先天性心脏传导阻滞与母亲的系统性红斑狼疮
Congenital heart block and maternal systemic lupus erythematosus.
作者信息
Esscher E, Scott J S
出版信息
Br Med J. 1979 May 12;1(6173):1235-8. doi: 10.1136/bmj.1.6173.1235.
Abstract
The association between infants with congenital heart block (CHB) and the presence or later development of maternal systemic lupus erythematosus or other connective-tissue disease (CTD) was reviewed in 67 cases. In 24 cases CHB was diagnosed at or before birth. Of nine necropsies on affected infants, seven showed endomyocardial fibrosis. The results suggest that one in three mothers who deliver babies with CHB have or will develop CTD. The association is probably explained by placental transfer of a maternal antibody. Awareness of the association may lead to prevention of the birth of children with CHB and better neonatal care of affected children.
摘要
对67例先天性心脏传导阻滞（CHB）婴儿与母亲系统性红斑狼疮或其他结缔组织病（CTD）的存在或后期发展之间的关联进行了回顾。24例CHB在出生时或出生前被诊断。在对受影响婴儿进行的9次尸检中，7例显示心内膜心肌纤维化。结果表明，分娩患有CHB婴儿的母亲中有三分之一患有或将发展为CTD。这种关联可能是由母体抗体的胎盘转移所解释。认识到这种关联可能会预防患有CHB的儿童出生，并对受影响的儿童进行更好的新生儿护理。
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