Kalush F, Rimon E, Keller A, Mozes E
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
J Clin Immunol. 1994 Sep;14(5):314-22. doi: 10.1007/BF01540985.
Neonatal lupus erythematosus (NLE) syndrome is characterized by a transient dermatitis, a variety of systemic and hematological abnormalities, and isolated cases of congenital complete heart block. The latter has been reported to be due to the presence of autoantibodies specific to La (SS-B) and/or Ro (SS-A). As female mice with experimental systemic lupus erythematosus (SLE) induced by immunization with the human monoclonal anti-DNA antibody bearing the 16/6 Id produce variety of autoantibodies including anti-Ro and anti-La antibodies, we looked for NLE related symptoms in the murine model. Offspring of BALB/c mice with SLE possessed high levels of autoantibodies that declined gradually till reduced to normal levels at day 60 after delivery. Electrocardiograms recorded in groups of offspring from mothers with experimental SLE indicated that a high percentage of the offspring had defects in their conductive system including first-, second-, and third-degree heart block, significant bradycardia, and a wide QRS complex. In contrast, a normal pattern was observed in offspring of healthy mothers.
新生儿红斑狼疮（NLE）综合征的特征为短暂性皮炎、多种全身和血液学异常以及孤立的先天性完全性心脏传导阻滞病例。据报道，后者是由于存在针对La（SS - B）和/或Ro（SS - A）的特异性自身抗体所致。由于用携带16/6独特型的人单克隆抗DNA抗体免疫诱导产生实验性系统性红斑狼疮（SLE）的雌性小鼠会产生包括抗Ro和抗La抗体在内的多种自身抗体，我们在该小鼠模型中寻找与NLE相关的症状。患有SLE的BALB/c小鼠的后代具有高水平的自身抗体，这些抗体在分娩后第60天逐渐下降直至降至正常水平。对患有实验性SLE的母亲的后代组进行的心电图记录表明，很大比例的后代存在传导系统缺陷，包括一度、二度和三度心脏传导阻滞、显著心动过缓和宽QRS波群。相比之下，健康母亲的后代观察到正常模式。
