Stadler J, Adelberg E A
J Bacteriol. 1972 Jan;109(1):447-9. doi: 10.1128/jb.109.1.447-449.1972.
Wild-type sex factors of Escherichia coli K-12 can be cured from host cells by growth at temperatures above 42 C. This phenomenon is obscured by reinfection of cured cells if the culture is allowed to reach cell densities above 10(5)/ml. The rate of episome loss is dependent on the genetic (chromosomal) background of the host.
大肠杆菌K-12的野生型性因子可通过在42℃以上的温度下生长从宿主细胞中消除。如果培养物的细胞密度达到10(5)/ml以上,治愈细胞的再次感染会掩盖这种现象。附加体丢失的速率取决于宿主的遗传(染色体)背景。