耐药因子Rts1复制中的热敏性损伤。
The thermosensitive lesion in the replication of the drug resistance factor, Rts1.
作者信息
DiJoseph C G
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2515-9. doi: 10.1073/pnas.71.6.2515.
Abstract
The DNA of the thermosensitive R factor, Rts1, has been examined by the technique of sedimentation in alkaline sucrose density gradients. Rts1 DNA was found as closed covalent circles in only a few copies per cell in an Escherichia coli host at the permissive temperature. Rts1 DNA appears to be synthesized at the nonpermissive temperature, but was not found as closed covalent circles. However, circular DNA could be recovered upon shift down to the permissive temperature. The large number of plasmid-negative cells which accumulate after prolonged culture at non-permissive temperature may be due to a strong selective pressure favoring the growth of rare R(-) segregants.
摘要
利用碱性蔗糖密度梯度沉降技术对温度敏感型R因子Rts1的DNA进行了检测。在允许温度下，Rts1 DNA在大肠杆菌宿主细胞中仅以每个细胞几个拷贝的形式呈现为闭合共价环。Rts1 DNA似乎在非允许温度下合成，但未发现其以闭合共价环的形式存在。然而，当温度降至允许温度时，可回收环状DNA。在非允许温度下长时间培养后积累的大量质粒阴性细胞，可能是由于强烈的选择压力有利于罕见的R(-)分离株生长所致。
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