Adelstein P, Baldwin J A, Fedrich J
Cancer. 1979 Jun;43(6):2553-7. doi: 10.1002/1097-0142(197906)43:6<2553::aid-cncr2820430657>3.0.co;2-y.
The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associated. In males significant associations were shown between cancers of the large bowel and cancer of the prostate. In females, cancer of the colon was associated with breast cancer, and cancer of the rectum with a mixed group of genital cancers. The relative risk of colorectal cancer associated with previous benign neoplasms of the large bowel was 20, and with ulcerative colitis, 25. There was no significant association with appendicitis or long-standing diverticular disease.
对牛津记录链接研究1963年至1967年档案中的个体病史进行分析，以确定个体中大肠癌与其他疾病之间任何先前未被怀疑的关联，并量化已知相关疾病的相对风险。在男性中，大肠癌与前列腺癌之间存在显著关联。在女性中，结肠癌与乳腺癌相关，直肠癌与一组混合性生殖系统癌症相关。与大肠先前良性肿瘤相关的结直肠癌相对风险为20，与溃疡性结肠炎相关的为25。与阑尾炎或长期憩室病无显著关联。
