广泛性溃疡性结肠炎的癌症风险
Cancer risk in extensive ulcerative colitis.
作者信息
Kewenter J, Ahlman H, Hultén L
出版信息
Ann Surg. 1978 Dec;188(6):824-8. doi: 10.1097/00000658-197812000-00018.
Abstract
Two hundred thirty-four patients with extensive ulcerative colitis from the city of Göteborg, Sweden have been followed up and the cumulative risk of development of cancer of the large bowel was estimated. These patients constitute all persons in this region who developed an extensive ulcerative colitis between 1951 and 1974. All patients were followed up until December 1975. The mean observation time was 8.5 years, median value six years. Fifteen patients developed carcinoma of the large bowel. Five of the 15 patients were still alive in December 1975. The expected number of colorectal carcinomas in a matched reference group was 0.49. The cumulative incidence of carcinoma 25 years after the onset of colitis for the whole group of patients was 34% and for those who developed the disease before 25 years of age it was 43%.
摘要
对瑞典哥德堡市的234例广泛性溃疡性结肠炎患者进行了随访，并估算了发生大肠癌的累积风险。这些患者构成了该地区1951年至1974年间罹患广泛性溃疡性结肠炎的所有病例。所有患者均随访至1975年12月。平均观察时间为8.5年，中位数为6年。15例患者发生了大肠癌。1975年12月时，这15例患者中有5例仍存活。在匹配的参照组中，结直肠癌的预期病例数为0.49。整个患者组在结肠炎发病25年后的癌症累积发病率为34%，25岁之前发病的患者该发病率为43%。
相似文献
1
Cancer risk in extensive ulcerative colitis.广泛性溃疡性结肠炎的癌症风险
Ann Surg. 1978 Dec;188(6):824-8. doi: 10.1097/00000658-197812000-00018.
2
Studies in longstanding ulcerative colitis with special reference to malignant transformation of the colorectal mucosa.关于长期溃疡性结肠炎的研究，特别提及结直肠黏膜的恶性转化。
Acta Chir Scand Suppl. 1989;552:1-45.
3
Colorectal and extracolonic malignancy in ulcerative colitis.溃疡性结肠炎中的结直肠癌及结外恶性肿瘤
Cancer. 1986 Oct 1;58(7):1569-74. doi: 10.1002/1097-0142(19861001)58:7<1569::aid-cncr2820580731>3.0.co;2-u.
4
Carcinoma and epithelial dysplasia complicating ulcerative colitis.溃疡性结肠炎并发的癌和上皮发育异常。
Gastroenterology. 1975 May;68(5 Pt 1):1127-36.
5
Malignancy in ulcerative colitis.溃疡性结肠炎中的恶性肿瘤
Scand J Gastroenterol. 1989 May;24(4):497-506. doi: 10.3109/00365528909093080.
6
Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.溃疡性结肠炎中的结直肠癌：一项来自三个中心的初级转诊队列研究。
Gut. 1988 Feb;29(2):206-17. doi: 10.1136/gut.29.2.206.
7
Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis.溃疡性结肠炎和克罗恩病：广泛性结肠炎患者结直肠癌风险的比较
Gut. 1994 Nov;35(11):1590-2. doi: 10.1136/gut.35.11.1590.
8
Ulcerative colitis and colorectal cancer. A population-based study.溃疡性结肠炎与结直肠癌。一项基于人群的研究。
N Engl J Med. 1990 Nov 1;323(18):1228-33. doi: 10.1056/NEJM199011013231802.
9
The risk of colorectal cancer in ulcerative colitis. An epidemiologic study.溃疡性结肠炎患者患结直肠癌的风险。一项流行病学研究。
Scand J Gastroenterol. 1987 Dec;22(10):1193-9. doi: 10.3109/00365528708996463.
10
[Synchronous, multiple cancer of the large intestine against a background of nonspecific ulcerative colitis].
Klin Khir (1962). 1980 May(5):60-1.
引用本文的文献
1
The Importance of Post-Inflammatory Polyps (PIPs) in Colorectal Cancer Surveillance in Inflammatory Bowel Diseases.炎症后息肉（PIPs）在炎症性肠病结直肠癌监测中的重要性
J Clin Med. 2025 Jan 8;14(2):333. doi: 10.3390/jcm14020333.
2
Colorectal cancer and dysplasia risk of ulcerative colitis patients in a tertiary referral center in Turkey.土耳其一家三级转诊中心溃疡性结肠炎患者的结直肠癌及发育异常风险
Turk J Gastroenterol. 2019 Feb;30(2):139-147. doi: 10.5152/tjg.2018.18221.
3
3-(1H-Benzo[]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.3-(1H-苯并[imidazol-6-yl)-5-(4-氟苯基)-1,2,4-恶二唑（DDO7232），一种新型有效的 Nrf2/ARE 诱导剂，通过 ERK1/2 磷酸化改善 DSS 诱导的小鼠结肠炎并保护 NCM460 细胞免受氧化应激。
Oxid Med Cell Longev. 2018 May 20;2018:3271617. doi: 10.1155/2018/3271617. eCollection 2018.
4
Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists.中国与美国胃肠病理亚专科医生对炎症性肠病相关肿瘤诊断的观察者间一致性比较
Gastroenterol Res Pract. 2018 Apr 23;2018:8715263. doi: 10.1155/2018/8715263. eCollection 2018.
5
Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.炎症累积负担预测溃疡性结肠炎结直肠肿瘤风险：一项大型单中心研究。
Gut. 2019 Mar;68(3):414-422. doi: 10.1136/gutjnl-2017-314190. Epub 2017 Nov 17.
6
Update on inflammatory bowel disease in patients with primary sclerosing cholangitis.原发性硬化性胆管炎患者炎症性肠病的最新情况
World J Hepatol. 2014 Apr 27;6(4):178-87. doi: 10.4254/wjh.v6.i4.178.
7
Inflammatory Bowel Disease Associated Colorectal Neoplasia.炎症性肠病相关结直肠肿瘤
J Gastrointest Dig Syst. 2012 Jan 23;Suppl 8:002. doi: 10.4172/2161-069X.S8-002.
8
Risk of ulcerative colitis-associated colorectal cancer in China: a multi-center retrospective study.中国溃疡性结肠炎相关性结直肠癌的风险：一项多中心回顾性研究。
Dig Dis Sci. 2012 Feb;57(2):503-7. doi: 10.1007/s10620-011-1890-9. Epub 2011 Sep 22.
9
Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin.紧密连接蛋白和黏附连接蛋白在溃疡性结肠炎相关结直肠癌中的表达：紧密连接蛋白-1、紧密连接蛋白-3、紧密连接蛋白-4和β-连环蛋白的上调。
Int J Colorectal Dis. 2009 Apr;24(4):361-8. doi: 10.1007/s00384-009-0653-y. Epub 2009 Jan 29.
10
Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.原发性直肠CD56+自然杀伤/T细胞淋巴瘤伴难治性溃疡性结肠炎。
J Gastroenterol. 2008;43(7):576-80. doi: 10.1007/s00535-008-2192-7. Epub 2008 Jul 23.
本文引用的文献
1
THE CANCER RISK IN ULCERATIVE COLITIS.溃疡性结肠炎中的癌症风险
Lancet. 1964 Sep 26;2(7361):655-8. doi: 10.1016/s0140-6736(64)92474-2.
2
Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum.溃疡性结肠炎的局部并发症：狭窄、假息肉形成以及结肠和直肠癌。
Br Med J. 1966 Jun 11;1(5501):1442-7. doi: 10.1136/bmj.1.5501.1442.
3
Risk of malignant change in ulcerative colitis.溃疡性结肠炎发生恶变的风险。
Gut. 1966 Oct;7(5):427-32. doi: 10.1136/gut.7.5.427.
4
Ulcerative proctocolitis in Czechoslovakia.
Am J Proctol. 1968 Apr;19(2):106-14.
5
Ulcerative colitis in Turkey: clinical review of sixty cases.土耳其的溃疡性结肠炎：60例临床回顾
Dis Colon Rectum. 1970 Jan-Feb;13(1):62-5. doi: 10.1007/BF02617689.
6
Cancer risk and life expectancy of children with ulcerative colitis.溃疡性结肠炎患儿的癌症风险和预期寿命。
N Engl J Med. 1971 Jul 1;285(1):17-21. doi: 10.1056/NEJM197107012850103.
7
In-situ and invasive carcinoma of the colon in patients with ulcerative colitis.溃疡性结肠炎患者的结肠原位癌和浸润癌。
Gut. 1972 Jul;13(7):566-70. doi: 10.1136/gut.13.7.566.
8
The quality of life after proctocolectomy and ileostomy: a study of patients with conventional ileostomies converted to continent ileostomies.
Dis Colon Rectum. 1974 May-Jun;17(3):287-92. doi: 10.1007/BF02586968.
9
Ulcerative colitis in the Jewish population of Tel-Aviv Uafo. II: The rarity of malignant degeneration.特拉维夫雅法犹太人群中的溃疡性结肠炎。II：恶性变的罕见性。
Gastroenterology. 1974 Nov;67(5):933-8.
10
Precancer and carcinoma in chronic ulcerative colitis. A histopathological and clinical investigation.慢性溃疡性结肠炎中的癌前病变和癌。一项组织病理学与临床研究。
Scand J Gastroenterol. 1972;7(7):663-9. doi: 10.3109/00365527209180974.
Zotero 插件