Israel V, Woodworth-Gutai M, Levine M
J Virol. 1972 May;9(5):752-7. doi: 10.1128/JVI.9.5.752-757.1972.
Infection of Salmonella typhimurium with phage P22 causes a decrease in the activity of host deoxyribonuclease which degrades single-stranded deoxyribonucleic acid (DNA). This decrease is reversed when the infecting phage is P22c(+); it is not reversed if the infecting phage kills the cell. The decrease does not occur in infections with P22ts25.1 (which only adsorbs and injects DNA) or in infections of a lysogen by a nonvirulent phage. It does occur, however, after infections with other phages which are blocked in phage DNA synthesis. Inhibiting protein synthesis with chloramphenicol does not in itself cause the decrease in uninfected cells, but it does prevent infected cells from showing this effect.
鼠伤寒沙门氏菌被噬菌体P22感染会导致宿主脱氧核糖核酸酶活性降低，该酶可降解单链脱氧核糖核酸（DNA）。当感染的噬菌体为P22c(+)时，这种降低会逆转；如果感染的噬菌体杀死细胞，则不会逆转。用P22ts25.1（仅吸附并注入DNA）感染或用无毒噬菌体感染溶原菌时，这种降低不会发生。然而，在用其他在噬菌体DNA合成中受阻的噬菌体感染后，这种降低确实会发生。用氯霉素抑制蛋白质合成本身不会导致未感染细胞出现这种降低，但它确实能阻止感染细胞出现这种效应。
