Slutsky R, Karliner J, Ricci D, Kaiser R, Pfisterer M, Gordon D, Peterson K, Ashburn W
Circulation. 1979 Sep;60(3):556-64. doi: 10.1161/01.cir.60.3.556.
To compare radionuclide end-diastolic (EDV) and end-systolic (ESV) volumes with angiographic volume, we studied 52 patients with equilibrium radionuclide angiography using 99mTc-human serum albumin within 48 hours of contrast angiography. Each RR interval was divided into 20--28 equally timed frames and a time-activity curve generated. End-diastolic counts were taken at the early peak of the curve and end-systolic counts at its nadir. Counts were divided by the total number of processed heart beats and normalized for: 1) dose per body surface area; 2) plasma volume; and 3) counts/ml of plasma. A cardiac phantom was developed and serial volumes were studied using a normalization factor. Radionuclide values were expressed as dimensionless units and compared with either biplane angiographic volumes (in the patient studies) or known phantom volumes. Good correlations were obtained with methods 1 and 2 in 35 patients (r greater than 0.84), but the best correlation was obtained in 17 patients when normalization for counts/ml of plasma was used (r = 0.98; y = 0.255 x -0.121). The standard error of the estimate (SEE) was +/- 11.5 ml for EDV and +/- 7.3 ml for ESV. The phantom study also showed an excellent correlation (r = 0.99), with a SEE of +/- 6.5 ml. We conclude that a radionuclide method independent of geometric assumptions can be used to estimate left ventricular volume in man.
为了比较放射性核素舒张末期（EDV）和收缩末期（ESV）容积与血管造影容积，我们在52例患者中进行了研究。这些患者在进行造影血管造影后48小时内使用99mTc - 人血清白蛋白进行平衡放射性核素血管造影。每个RR间期被分为20 - 28个等时帧，并生成时间 - 活性曲线。舒张末期计数取曲线的早期峰值，收缩末期计数取其最低点。计数除以处理的总心跳数，并针对以下因素进行归一化：1）每体表面积的剂量；2）血浆容积；3）每毫升血浆的计数。制作了一个心脏模型，并使用归一化因子研究了系列容积。放射性核素值以无量纲单位表示，并与双平面血管造影容积（在患者研究中）或已知的模型容积进行比较。在35例患者中，方法1和方法2获得了良好的相关性（r大于0.84），但当使用每毫升血浆计数的归一化方法时，在17例患者中获得了最佳相关性（r = 0.98；y = 0.255x - 0.121）。舒张末期容积的估计标准误差（SEE）为±11.5 ml，收缩末期容积为±7.3 ml。模型研究也显示出极好的相关性（r = 0.99），SEE为±6.5 ml。我们得出结论，一种独立于几何假设的放射性核素方法可用于估计人体左心室容积。
