脱氧核糖核酸酶抑制剂水平与NZB - NZW小鼠中抗核抗体出现的关系。
The relation of deoxyribonuclease inhibitor levels to the occurrence of antinuclear antibodies in NZB-NZW mice.
作者信息
Hadjiyannaki K, Lachmann P J
出版信息
Clin Exp Immunol. 1972 Jun;11(2):291-5.
Abstract
The level of heat-labile DNase 1 inhibitor in the serum of NZB/NZW F mice has been found to be significantly higher in animals having antinuclear antibodies. The inhibitor level in the hybrid mice without antinuclear antibodies was not significantly different from that found in control groups of NZB, NZW and BALB/c mice. These findings are discussed in the light of the hypothesis that excessive inhibition of DNase may play a part in rendering DNA nucleoproteins antigenic.
摘要
已发现，在具有抗核抗体的NZB/NZW F小鼠血清中，热不稳定DNase 1抑制剂的水平显著更高。没有抗核抗体的杂交小鼠中的抑制剂水平与在NZB、NZW和BALB/c小鼠对照组中发现的水平没有显著差异。根据DNase过度抑制可能在使DNA核蛋白具有抗原性方面起作用这一假设，对这些发现进行了讨论。
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本文引用的文献
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Clin Exp Immunol. 1968 Jun;3(5):447-55.
2
The immunology and pathology of NZB mice.NZB小鼠的免疫学与病理学
Adv Immunol. 1968;9:215-66. doi: 10.1016/s0065-2776(08)60444-7.
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