Brown W R, Butterfield D, Savage D, Tada T
Gut. 1972 Jun;13(6):441-9. doi: 10.1136/gut.13.6.441.
Seven patients with gastrointestinal disorders and deficiencies of serum and secretory immunoglobulins were evaluated clinically, microbiologically, and immunologically. Five patients had generalized deficiencies of immunoglobulins; two were selectively deficient. Diarrhoea and malabsorption in six of the seven patients were at least partially explained. Four of the five patients with generalized hypogammaglobulinaemia had intestinal infestation with Giardia lamblia; in three of the five, excessive numbers of anaerobic bacteria were cultured from small bowel fluids. Despite much variability in relative severity of patients' respiratory and gastrointestinal tract symptoms, deficiencies of mucosal immunocytes and immunoglobulins in nasopharyngeal and gastrointestinal tract tissues and secretions were similar. Except for one selectively IgA-deficient patient, all patients were deficient in IgE. The study characterizes in greater detail than heretofore the gastrointestinal disorders associated with immunoglobulin deficiency states.
对7例患有胃肠道疾病且血清和分泌型免疫球蛋白缺乏的患者进行了临床、微生物学和免疫学评估。5例患者存在全身性免疫球蛋白缺乏；2例为选择性缺乏。7例患者中有6例的腹泻和吸收不良至少部分得到了解释。5例全身性低丙种球蛋白血症患者中有4例肠道感染了蓝氏贾第鞭毛虫；5例中有3例从小肠液中培养出大量厌氧菌。尽管患者呼吸道和胃肠道症状的相对严重程度差异很大，但鼻咽和胃肠道组织及分泌物中的黏膜免疫细胞和免疫球蛋白缺乏情况相似。除1例选择性IgA缺乏患者外，所有患者均缺乏IgE。该研究比以往更详细地描述了与免疫球蛋白缺乏状态相关的胃肠道疾病。
