T淋巴细胞对人肠道B淋巴细胞的调控
Regulation of human gut B lymphocytes by T lymphocytes.
作者信息
Clancy R, Cripps A, Chipchase H
出版信息
Gut. 1984 Jan;25(1):47-51. doi: 10.1136/gut.25.1.47.
Abstract
The aims of this study were first, to assess whether or not immunoglobulin secretion from human gut mucosal B lymphocytes can be modified by T lymphocytes, and second whether human gut mucosal T lymphocytes are capable of regulating mucosal B lymphocyte function. T and B lymphocyte enriched cell populations were isolated from gut mucosa and co-cultured in varying proportions. Addition of T lymphocytes to B enriched mucosal cell populations (ratio B:T = 2:1) showed that mucosal B lymphocytes were responsive to T cell 'help'. Addition of more T cells (ratio B:T = 2:10) suppressed immunoglobulin synthesis.
摘要
本研究的目的，其一，评估人肠道黏膜B淋巴细胞的免疫球蛋白分泌是否可被T淋巴细胞改变；其二，评估人肠道黏膜T淋巴细胞是否能够调节黏膜B淋巴细胞功能。从肠道黏膜中分离出富含T和B淋巴细胞的细胞群体，并以不同比例进行共培养。向富含B淋巴细胞的黏膜细胞群体中添加T淋巴细胞（B:T比例=2:1）显示，黏膜B淋巴细胞对T细胞“辅助”有反应。添加更多T细胞（B:T比例=2:10）则会抑制免疫球蛋白合成。
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