Harding B, MacLennan I C
Immunology. 1972 Jul;23(1):35-43.
After intradermal injection of xenogeneic cells, antibody producing cells were demonstrated in the regional lymph nodes and peritoneal fluid as early as 5 days post-immunization. By 19 days antibody-producing cells were also found in the bone marrow, spleen and peripheral blood. They were not found in significant numbers in the thymus or non-regional lymph nodes. Antibody was demonstrable in the blood as early as 4 days post-immunization and reached maximum titre at 19 days. Both IgG and IgM were recovered from the thoracic duct lymph after intravenous injection. The significance of these findings is discussed in relation to the rejection of solid tumours and grafts.
在皮内注射异种细胞后，早在免疫后5天，在局部淋巴结和腹腔液中就可检测到抗体产生细胞。到19天时，在骨髓、脾脏和外周血中也发现了抗体产生细胞。在胸腺或非局部淋巴结中未发现大量此类细胞。早在免疫后4天血液中就可检测到抗体，在19天时达到最高滴度。静脉注射后，从胸导管淋巴液中可检测到IgG和IgM。结合实体瘤和移植物的排斥反应对这些发现的意义进行了讨论。
