大肠杆菌中的多核糖体代谢：抗生素对多核糖体稳定性的影响。
Polysome metabolism in Escherichia coli: effect of antibiotics on polysome stability.
作者信息
Ennis H L
出版信息
Antimicrob Agents Chemother. 1972 Mar;1(3):197-203. doi: 10.1128/AAC.1.3.197.
Abstract
A number of antibiotics, most of which specifically inhibit protein synthesis by interacting with the 50S ribosome subunit, were used to study polysome metabolism in vivo. The antibiotics affected polysomes in two ways: (i) by allowing extensive breakdown of polysomes, or (ii) by stabilizing polysomes, even in the presence of the antibiotics of the first group. The results indicate that the effect of these antibiotics on polysome stability in vivo can, in many cases, be correlated to their in vitro mode of action.
摘要
多种抗生素被用于研究体内多核糖体代谢，其中大多数抗生素通过与50S核糖体亚基相互作用来特异性抑制蛋白质合成。这些抗生素以两种方式影响多核糖体：（i）通过使多核糖体大量分解，或（ii）通过稳定多核糖体，即使在存在第一组抗生素的情况下也是如此。结果表明，在许多情况下，这些抗生素对体内多核糖体稳定性的影响与其体外作用模式相关。
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