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Antimicrob Agents Chemother. 1972 Mar;1(3):197-203. doi: 10.1128/AAC.1.3.197.
2
Polysome metabolism in Escherichia coli: amicetin, an antibiotic that stabilizes polysomes.大肠杆菌中的多核糖体代谢：氨甲环素，一种能稳定多核糖体的抗生素。
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6
Polysome metabolism in Escherichia coli: amicetin, an antibiotic that stabilizes polysomes.大肠杆菌中的多核糖体代谢：氨甲环素，一种能稳定多核糖体的抗生素。
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8
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9
Antibiotics of the virginiamycin family, inhibitors which contain synergistic components.维吉尼亚霉素家族的抗生素，含有协同成分的抑制剂。
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本文引用的文献

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Mutants of Escherichia coli requiring methionine or vitamin B12.需要甲硫氨酸或维生素B12的大肠杆菌突变体。
J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
2
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.嘌呤霉素对蛋白质合成的抑制作用：嘌呤霉素掺入肽链的过程。
Proc Natl Acad Sci U S A. 1964 Apr;51(4):585-92. doi: 10.1073/pnas.51.4.585.
3
Reaction of ribosome-bound peptidyl transfer ribonucleic acid with aminoacyl transfer ribonucleic acid or puromycin.核糖体结合肽基转移核糖核酸与氨酰基转移核糖核酸或嘌呤霉素的反应。
J Biol Chem. 1967 Dec 10;242(23):5564-71.
4
Effects of chloramphenicol and fusidic acid on polyribosome metabolism in escherichia coli.氯霉素和夫西地酸对大肠杆菌多核糖体代谢的影响。
FEBS Lett. 1969 Apr;3(1):34-36. doi: 10.1016/0014-5793(69)80089-x.
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Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis.核糖体催化的肽基转移：一些蛋白质合成抑制剂的作用
J Mol Biol. 1967 Aug 28;28(1):161-5. doi: 10.1016/s0022-2836(67)80085-8.
6
Increased stability of polysomes in an Escherichia coli mutant with relaxed control of RNA synthesis.在对RNA合成控制松弛的大肠杆菌突变体中多核糖体稳定性增加。
Proc Natl Acad Sci U S A. 1966 Aug;56(2):471-5. doi: 10.1073/pnas.56.2.471.
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Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes.
Biochim Biophys Acta. 1966 Feb 21;114(2):425-7. doi: 10.1016/0005-2787(66)90327-3.
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The requirement for potassium for bacteriophage T4 protein and deoxyribonucleic acid synthesis.噬菌体T4蛋白质和脱氧核糖核酸合成对钾的需求。
Virology. 1965 Nov;27(3):282-9. doi: 10.1016/0042-6822(65)90107-8.
9
Inhibition of protein synthesis by polypeptide antibiotics.. II. In vitro protein synthesis.多肽抗生素对蛋白质合成的抑制作用。II. 体外蛋白质合成
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10
Antibiotics and polyribosomes. II. Some effects of lincomycin, spiramycin, and streptogramin A in vivo.抗生素与多核糖体。II. 林可霉素、螺旋霉素和链阳性菌素A在体内的某些作用。
Biochemistry. 1969 May;8(5):2063-6. doi: 10.1021/bi00833a042.

大肠杆菌中的多核糖体代谢：抗生素对多核糖体稳定性的影响。

Polysome metabolism in Escherichia coli: effect of antibiotics on polysome stability.

作者信息

Ennis H L

出版信息

Antimicrob Agents Chemother. 1972 Mar;1(3):197-203. doi: 10.1128/AAC.1.3.197.

DOI:10.1128/AAC.1.3.197
PMID:4558138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444192/
Abstract

A number of antibiotics, most of which specifically inhibit protein synthesis by interacting with the 50S ribosome subunit, were used to study polysome metabolism in vivo. The antibiotics affected polysomes in two ways: (i) by allowing extensive breakdown of polysomes, or (ii) by stabilizing polysomes, even in the presence of the antibiotics of the first group. The results indicate that the effect of these antibiotics on polysome stability in vivo can, in many cases, be correlated to their in vitro mode of action.

摘要

多种抗生素被用于研究体内多核糖体代谢，其中大多数抗生素通过与50S核糖体亚基相互作用来特异性抑制蛋白质合成。这些抗生素以两种方式影响多核糖体：（i）通过使多核糖体大量分解，或（ii）通过稳定多核糖体，即使在存在第一组抗生素的情况下也是如此。结果表明，在许多情况下，这些抗生素对体内多核糖体稳定性的影响与其体外作用模式相关。