一例罕见的卡马西平中毒病例，在两天后出现近乎致命的复发。
An unusual case of carbamazepine poisoning with a near-fatal relapse after two days.
作者信息
de Zeeuw R A, Westenberg H G, van der Kleijn E, Gimbrère J S
出版信息
Clin Toxicol. 1979 Mar;14(3):263-9. doi: 10.3109/15563657908992443.
PMID:455916
Abstract
A severe case of carbamazepine is described in which the drug and its major metabolite were monitored by means of HPLC. After 2 days of treatment a dramatic rise in plasma concentration of carbamazepine and its metabolite was observed, accompanied by a relapse into deep coma, then followed by a rapid elimination of the drugs and complete recovery within 4 days. The possible mechanisms underlying these phenomena and potential therapeutic measures are discussed.
摘要
描述了一例严重的卡马西平病例，通过高效液相色谱法监测了该药物及其主要代谢物。治疗2天后，观察到卡马西平及其代谢物的血浆浓度急剧上升，同时患者再次陷入深度昏迷，随后药物迅速消除，并在4天内完全康复。讨论了这些现象背后的可能机制和潜在治疗措施。
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